University of Hertfordshire

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Keith Davies - Speaker

The Pasteuria group of Gram positive endospore forming bacteria have long been recognised as potential control agents for phytonematodes. However, two major aspects have inhibited their commercial development: a) the inability to culture the organisms outside it’s host, b) its host-specificity. A product using Pasteuria nishizawae as a seed treatment, CLARIVA, for the control of soybean cyst nematode is produced by Syngenta, but there is still no Pasteuria based product for the control of root-knot nematodes (Meloidogyne spp). Host-specificity is a major constraint for this latter group of nematodes as both the surface of the endospore and the surface of the cuticle are highly variable, and a compatible interaction is required if endospore deployment is to be successful in the field. Recent genomic sequence of Pasteuria penetrans has revealed 17 diverse collagen-like sequences that may be involved in producing the hair-like nap on the surface of the endospore that are likely to be involved in attachment as biochemical treatments that de-nature collagen reduce endospore attachment to the cuticle. Similar endospore attachment bioassays using RNAi have revealed that knockdown of a fatty acid retinol binding protein and mucin-like proteins amongst others in the nematode juvenile alters endospore adhesion. This research provides key insights into the mechanism of endospore attachment and therefore has implications for the successful deployment of Pasteuria in the field.
2 Jul 2019

Event (Conference)

TitleBiopesticide Summit 2019
Web address (URL)
LocationUniversity of Swansea
CountryUnited Kingdom
Degree of recognitionInternational event

ID: 16952108