University of Hertfordshire

Dr Andrei Tarasov

Lecturer

Publications

  1. 2019
  2. Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

    Haythorne, E., Rohm, M., van de Bunt, M., Brereton, M. F., Tarasov, A. I., Blacker, T. S., Sachse, G., Silva Dos Santos, M., Terron Exposito, R., Davis, S., Baba, O., Fischer, R., Duchen, M. R., Rorsman, P., MacRae, J. I. & Ashcroft, F. M., 6 Jun 2019, In : Nature Communications. 10, 1, p. 2474 2474.

    Research output: Contribution to journalArticle

  3. Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production

    Knudsen, J. G., Hamilton, A., Ramracheya, R., Tarasov, A. I., Brereton, M., Haythorne, E., Chibalina, M. V., Spégel, P., Mulder, H., Zhang, Q., Ashcroft, F. M., Adam, J. & Rorsman, P., 5 Feb 2019, In : Cell metabolism. 29, 2, p. 430-442

    Research output: Contribution to journalArticle

  4. Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

    Vergari, E., Knudsen, J. G., Ramracheya, R., Salehi, A., Zhang, Q., Adam, J., Asterholm, I. W., Benrick, A., Briant, L. J. B., Chibalina, M. V., Gribble, F. M., Hamilton, A., Hastoy, B., Reimann, F., Rorsman, N. J. G., Spiliotis, I. I., Tarasov, A., Wu, Y., Ashcroft, F. M. & Rorsman, P., 11 Jan 2019, In : Nature Communications. 10, 1, p. 139 1 p., 139.

    Research output: Contribution to journalArticle

  5. 2018
  6. Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells

    Hastoy, B., Godazgar, M., Clark, A., Nylander, V., Spiliotis, I., van de Bunt, M., Chibalina, M. V., Barrett, A., Burrows, C., Tarasov, A. I., Scharfmann, R., Gloyn, A. L. & Rorsman, P., 19 Nov 2018, In : Scientific Reports. 8, 1, p. 1-16 16994.

    Research output: Contribution to journalArticle

  7. Monitoring real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis

    Tarasov, A. I., Galvanovskis, J., Rorsman, O., Hamilton, A., Vergari, E., Johnson, P. R. V., Reimann, F., Ashcroft, F. M. & Rorsman, P., 30 Jul 2018, In : Lab on a Chip. 18, p. 2838-2848 11 p.

    Research output: Contribution to journalArticle

  8. Adrenaline stimulates glucagon secretion by Tpc2-Dependent ca 2+ mobilization from acidic stores in pancreatic a-Cells

    Hamilton, A., Zhang, Q., Salehi, A., Willems, M., Knudsen, J. G., Ringgaard, A. K., Chapman, C. E., Gonzalez-Alvarez, A., Surdo, N. C., Zaccolo, M., Basco, D., Johnson, P. R. V., Ramracheya, R., Rutter, G. A., Galione, A., Rorsman, P. & Tarasov, A. I., 1 Jun 2018, In : Diabetes. 67, 6, p. 1128-1139 12 p.

    Research output: Contribution to journalArticle

  9. α-cell glucokinase suppresses glucose-regulated glucagon secretion

    Basco, D., Zhang, Q., Salehi, A., Tarasov, A., Dolci, W., Herrera, P., Spiliotis, I., Berney, X., Tarussio, D., Rorsman, P. & Thorens, B., 7 Feb 2018, In : Nature Communications. 9, 1, p. 1-9 9 p., 546.

    Research output: Contribution to journalArticle

  10. AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity

    Gorvin, C. M., Rogers, A., Hastoy, B., Tarasov, A. I., Frost, M., Sposini, S., Inoue, A., Whyte, M. P., Rorsman, P., Hanyaloglu, A. C., Breitwieser, G. E. & Thakker, R. V., 23 Jan 2018, In : Cell Reports. 22, 4, p. 1054-1066 13 p.

    Research output: Contribution to journalArticle

  11. 2017
  12. Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

    Adam, J., Ramracheya, R., Chibalina, M. V., Ternette, N., Hamilton, A., Tarasov, A. I., Zhang, Q., Rebelato, E., Rorsman, N. J. G., Martín-Del-Río, R., Lewis, A., Özkan, G., Do, H. W., Spégel, P., Saitoh, K., Kato, K., Igarashi, K., Kessler, B. M., Pugh, C. W., Tamarit-Rodriguez, J. & 8 othersMulder, H., Clark, A., Frizzell, N., Soga, T., Ashcroft, F. M., Silver, A., Pollard, P. J. & Rorsman, P., 26 Sep 2017, In : Cell Reports. 20, 13, p. 3135-3148 14 p.

    Research output: Contribution to journalArticle

  13. 2016
  14. Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion

    Collins, S. C., Do, H. W., Hastoy, B., Hugill, A., Adam, J., Chibalina, M. V., Galvanovskis, J., Godazgar, M., Lee, S., Goldsworthy, M., Salehi, A., Tarasov, A. I., Rosengren, A. H., Cox, R. & Rorsman, P., 1 Jul 2016, In : Diabetes. 65, 7, p. 1952-1961 10 p.

    Research output: Contribution to journalArticle

  15. Angular Approach Scanning Ion Conductance Microscopy

    Shevchuk, A., Tokar, S., Gopal, S., Sanchez-Alonso, J. L., Tarasov, A. I., Vélez-Ortega, A. C., Chiappini, C., Rorsman, P., Stevens, M. M., Gorelik, J., Frolenkov, G. I., Klenerman, D. & Korchev, Y. E., 24 May 2016, In : Biophysical Journal. 110, 10, p. 2252-2265 14 p.

    Research output: Contribution to journalArticle

  16. Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1

    Tarasov, A. I. & Rorsman, P., 12 Jan 2016, In : Cell metabolism. 23, 1, p. 8-10 3 p.

    Research output: Contribution to journalArticle

  17. 2015
  18. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

    Shigeto, M., Ramracheya, R., Tarasov, A. I., Cha, C. Y., Chibalina, M. V., Hastoy, B., Philippaert, K., Reinbothe, T., Rorsman, N., Salehi, A., Sones, W. R., Vergari, E., Weston, C., Gorelik, J., Katsura, M., Nikolaev, V. O., Vennekens, R., Zaccolo, M., Galione, A., Johnson, P. R. V. & 3 othersKaku, K., Ladds, G. & Rorsman, P., 1 Dec 2015, In : Journal of Clinical Investigation. 125, 12, p. 4714-28 15 p.

    Research output: Contribution to journalArticle

  19. 2014
  20. Incretin-modulated beta cell energetics in intact islets of Langerhans

    Hodson, D. J., Tarasov, A. I., Gimeno Brias, S., Mitchell, R. K., Johnston, N. R., Haghollahi, S., Cane, M. C., Bugliani, M., Marchetti, P., Bosco, D., Johnson, P. R., Hughes, S. J. & Rutter, G. A., 1 Jun 2014, In : Molecular endocrinology (Baltimore, Md.). 28, 6, p. 860-71 12 p.

    Research output: Contribution to journalArticle

  21. Use of genetically encoded sensors to monitor cytosolic ATP/ADP ratio in living cells

    Tarasov, A. I. & Rutter, G. A., 24 May 2014, In : Methods in Enzymology. 542, p. 289-311 23 p.

    Research output: Contribution to journalArticle

  22. 2013
  23. Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes

    Zhang, Q., Ramracheya, R., Lahmann, C., Tarasov, A., Bengtsson, M., Braha, O., Braun, M., Brereton, M., Collins, S., Galvanovskis, J., Gonzalez, A., Groschner, L. N., Rorsman, N. J. G., Salehi, A., Travers, M. E., Walker, J. N., Gloyn, A. L., Gribble, F., Johnson, P. R. V., Reimann, F. & 2 othersAshcroft, F. M. & Rorsman, P., 3 Dec 2013, In : Cell metabolism. 18, 6, p. 871-82 12 p.

    Research output: Contribution to journalArticle

  24. 2012
  25. Frequency-dependent mitochondrial Ca(2+) accumulation regulates ATP synthesis in pancreatic β cells

    Tarasov, A. I., Semplici, F., Li, D., Rizzuto, R., Ravier, M. A., Gilon, P. & Rutter, G. A., 14 Nov 2012, In : Pflugers Archiv European Journal of Physiology. 465, 4, p. 543-554 12 p.

    Research output: Contribution to journalArticle

  26. The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells

    Tarasov, A. I., Semplici, F., Ravier, M. A., Bellomo, E. A., Pullen, T. J., Gilon, P., Sekler, I., Rizzuto, R. & Rutter, G. A., 19 Jul 2012, In : PLoS ONE. 7, 7, 12 p., e39722.

    Research output: Contribution to journalArticle

  27. Regulation of ATP production by mitochondrial Ca(2+)

    Tarasov, A. I., Griffiths, E. J. & Rutter, G. A., Jul 2012, In : Cell Calcium. 52, 1, p. 28-35 8 p.

    Research output: Contribution to journalReview article

  28. 2011
  29. Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR)

    Li, D., Chen, S., Bellomo, E. A., Tarasov, A. I., Kaut, C., Rutter, G. A. & Li, W., 27 Dec 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 52, p. 21063-8 6 p.

    Research output: Contribution to journalArticle

  30. 2010
  31. LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo

    Sun, G., Tarasov, A. I., McGinty, J. A., French, P. M., McDonald, A., Leclerc, I. & Rutter, G. A., Jun 2010, In : American journal of physiology. Endocrinology and metabolism. 298, 6, p. E1261-73

    Research output: Contribution to journalArticle

  32. Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo

    Sun, G., Tarasov, A. I., McGinty, J., McDonald, A., da Silva Xavier, G., Gorman, T., Marley, A., French, P. M., Parker, H., Gribble, F., Reimann, F., Prendiville, O., Carzaniga, R., Viollet, B., Leclerc, I. & Rutter, G. A., May 2010, In : Diabetologia. 53, 5, p. 924-36 13 p.

    Research output: Contribution to journalArticle

  33. Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention

    Meur, G., Simon, A., Harun, N., Virally, M., Dechaume, A., Bonnefond, A., Fetita, S., Tarasov, A. I., Guillausseau, P-J., Boesgaard, T. W., Pedersen, O., Hansen, T., Polak, M., Gautier, J-F., Froguel, P., Rutter, G. A. & Vaxillaire, M., Mar 2010, In : Diabetes. 59, 3, p. 653-61 9 p.

    Research output: Contribution to journalArticle

  34. 2009
  35. Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

    Nicolson, T. J., Bellomo, E. A., Wijesekara, N., Loder, M. K., Baldwin, J. M., Gyulkhandanyan, A. V., Koshkin, V., Tarasov, A. I., Carzaniga, R., Kronenberger, K., Taneja, T. K., da Silva Xavier, G., Libert, S., Froguel, P., Scharfmann, R., Stetsyuk, V., Ravassard, P., Parker, H., Gribble, F. M., Reimann, F. & 13 othersSladek, R., Hughes, S. J., Johnson, P. R. V., Masseboeuf, M., Burcelin, R., Baldwin, S. A., Liu, M., Lara-Lemus, R., Arvan, P., Schuit, F. C., Wheeler, M. B., Chimienti, F. & Rutter, G. A., Sep 2009, In : Diabetes. 58, 9, p. 2070-83 14 p.

    Research output: Contribution to journalArticle

  36. TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

    da Silva Xavier, G., Loder, M. K., McDonald, A., Tarasov, A. I., Carzaniga, R., Kronenberger, K., Barg, S. & Rutter, G. A., Apr 2009, In : Diabetes. 58, 4, p. 894-905 12 p.

    Research output: Contribution to journalArticle

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