University of Hertfordshire

Dr Maria Schilstra

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Dr. Maria Schilstra

  • Centre for Computer Science and Informatics Research

Email: m.j.1.schilstra@herts.ac.uk

Research output

The dependence of arithmetic operations on input location in cerebellar nucleus and cortical pyramidal neurons

Psarrou, M., Schilstra, M., Davey, N., Torben-Nielsen, B., Schmuker, M. & Steuber, V., 2017, In : BMC Neuroscience. 18, 1, p. P257

Input-location dependent gain modulation in cerebellar nucleus neurons

Psarrou, M., Schilstra, M., Davey, N., Torben-Nielsen, B. & Steuber, V., 18 Aug 2016, In : BMC Neuroscience. 17, Supplement 1, 7.

The role of cerebellar short-term synaptic plasticity in the pathology and medication of downbeat nystagmus

Goncharenko, J., Davey, N., Schilstra, M. & Steuber, V., 18 Aug 2016, In : BMC Neuroscience. 17, p. P51

Unravelling how βCaMKII controls the direction of plasticity at parallel fibre-Purkinje cell synapses

Pinto, T. M., Schilstra, M. J., Steuber, V. & Roque, A. C., 31 Dec 2015, International Conference of Computational Methods in Sciences and Engineering 2015, ICCMSE 2015. American Institute of Physics Inc., Vol. 1702. 130002

Symmetry structure in discrete models of biochemical systems: natural subsystems and the weak control hierarchy in a new model of computation driven by interactions

Nehaniv, C. L., Rhodes, J., Egri-Nagy, A., Dini, P., Rothstein Morris, E., Horvath, G., Karimi, F., Schreckling, D. & Schilstra, M., 28 Jul 2015, In : Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 373, 51 p., 20140223.

βCaMKII regulates bidirectional long-term plasticity in cerebellar Purkinje cells by a CaMKII/PP2B switch mechanism

Matos Pinto, T., Schilstra, M., Steuber, V. & Roque, A., 21 Jul 2014, In : BMC Neuroscience. 15, Supp 1, p. P58 2 p.

Evolving spiking neural networks for temporal pattern recognition in the presence of noise

Abdelmotaleb, A., Davey, N., Schilstra, M., Steuber, V. & Wrobel, B., 2014, Artificial Life 2014: Procs of the Fourteenth International Conference on the Synthesis and Simulation of Living Systems. Sayama, H. (ed.). MIT Press, p. 965-972

Exploring the concept of interaction computing through the discrete algebraic analysis of the Belousov-Zhabotinsky reaction

Dini, P., Nehaniv, C. L., Egri-Nagy, A. & Schilstra, M., May 2013, In : Biosystems. 112, 2, p. 145-162 18 p.

Filamentous actin binding enables betaCaMKII to regulate bidirectional plasticity in cerebellar Purkinje cells

Pinto, T. M., Schilstra, M. & Steuber, V., 2013, In : BMC Neuroscience. 14, Supp 1, 2 p., P375.

From evolving artificial gene regulatory networks to evolving spiking neural networks for pattern recognition

Abdelmotaleb, A., Schilstra, M., Davey, N., Steuber, V. & Wrobel, B., 2013, In : BMC Neuroscience. 14, Supp 1, 1 p., P423.

A knowledge-based diagnostic clinical decision support system for musculoskeletal disorders of the shoulder for use in a primary care setting

Farmer, N. & Schilstra, M., 2012, In : Shoulder and Elbow. 4, 2, p. 141-151 11 p.

Algebraic analysis of the computation in the Belousov-Zhabotinsky reaction

Dini, P., Nehaniv, C. L., Egri-Nagy, A. & Schilstra, M., 2012, Information Processing in Cells and Tissues. Springer, p. 216-224 9 p. (Lecture Notes in Computer Science; vol. 7223).

BIOMICS Project: Biological and Mathematical Basis of Interaction Computing

Dini, P., Nehaniv, C. L., Egri-Nagy, A., Schilstra, M., Schreckling, D., Posegga, J., Horvath, G. & Munro, A. J., 2012, In : International Journal of Unconventional Computing. 8, 4, p. 283-287 5 p.

Does CamKII decode ca2+ oscillations?

Pinto, T. M., Schilstra, M. & Steuber, V., 2012, In : BMC Neuroscience. 13, Supp 1, 2 p., O15.

The effective calcium/calmodulin concentration determines the sensitivity of CaMKII to the frequency of calcium oscillations

Pinto, T. M., Schilstra, M. & Steuber, V., 2012, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 7223 LNCS. p. 131-135 5 p.

Transformation semigroups as constructive dynamical spaces

Egri-Nagy, A., Dini, P., Nehaniv, C. L. & Schilstra, M. J., 1 Dec 2010, Digital Ecosystems - Third International Conference, OPAALS 2010, Revised Selected Papers. p. 245-265 21 p. (Lecture Notes of the Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering; vol. 67 LNICST).

Genetic algorithms and their application to in silico evolution of genetic regulatory networks

Knabe, J., Wegner, K., Nehaniv, C. L. & Schilstra, M., 2010, In : Methods in Molecular Biology. 673, 1, p. 297-321

Stochastic model of template-directed elongation processes in biology

Schilstra, M. & Nehaniv, C. L., 2010, In : Biosystems. 102, 1, p. 55-60

Simple stochastic simulation

Schilstra, M. & Martin, S. R., 2009, Methods in Enzymology: Computer Methods. Elsevier, Vol. 467. p. 381-409

Do Motifs Reflect Evolved Function? – No Convergent Evolution of Genetic Regulatory Network Subgraph Topologies

Knabe, J., Nehaniv, C. L. & Schilstra, M., Oct 2008, In : Biosystems. 94, 1-2, p. 68-74

Automatic Analysis of Computation in BioChemical Reactions

Egri-Nagy, A., Nehaniv, C. L., Rhodes, J. L. & Schilstra, M., 2008, In : Biosystems. 94, 1-2, p. 126-134

Bio-logic: gene expression and the laws of combinatorial logic

Schilstra, M. & Nehaniv, C. L., 2008, In : Artificial Life. 14, 1, p. 121-133

Circular Dichroism and Its Application to the Study of Biomolecules

Martin, S. R. & Schilstra, M., 2008, In : Methods in Cell Biology. 84, p. 263-293

Evolution and morphogenesis of differentiated multicellular organisms: autonomously generated diffusion gradients for positional information

Knabe, J., Schilstra, M. & Nehaniv, C. L., 2008, Artificial Life XI: Procs of the 11th Int Conf on the Simulation and Synthesis of Living Systems.. MIT Press, p. 321-328

Genetic regulatory network models of biological clocks: evolutionary history matters

Knabe, J. F., Nehaniv, C. L. & Schilstra, M., 2008, In : Artificial life. 14, 1, p. 135-148

Methods for Simulating the Dynamics of Complex Biological Processes

Schilstra, M., Martin, S. R. & Keating, S., 2008, In : Methods in Cell Biology. 84, p. 807-842

Rapid Kinetic Techniques

Eccleston, J. F., Martin, S. R. & Schilstra, M., 2008, In : Methods in Cell Biology. 84, p. 445-477

Regulation of gene regulation - smooth binding with dynamic affinity affects evolvability

Knabe, J., Nehaniv, C. L. & Schilstra, M., 2008, IEEE Congress on Evolutionary Computation, CEC 2008. IEEE, p. 890-896

SBML models and MathSBML

Shapiro, B. E., Finney, A., Hucka, M., Bornstein, B., Funahashi, A., Jouraku, A., Keating, S., Le Novere, N., Matthews, J. & Schilstra, M., 2007, Introduction to Systems Biology. Choi, S. (ed.). Human Press / Springer, p. 395-421

The Essential Motif that wasn't there: Topological and Lesioning Analysis of Evolved Genetic Regulatory Networks

Knabe, J., Nehaniv, C. L. & Schilstra, M., 2007, In: IEEE Symposium on Artificial Life, ALIFE'07. IEEE, p. 69-76

The NetBuilder project: development of a tool for constructing, simulating, evolving, and analysing complex regulatory networks

Wegner, K., Knabe, J., Robinson, M., Egri-Nagy, A. & Schilstra, M., 2007, In : BMC Systems Biology. 1, Suppl 1

An elastically tethered viscous load imposes a regular gait on the motion of myosin-V. Simulation of the effect of transient force relaxation on a stochastic process

Schilstra, M. & Martin, S. R., 2006, In : Journal of The Royal Society Interface. 3, 6, p. 153-165

BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems

Le Novere, N., Bornstein, B., Broicher, A., Courtot, M., Donizelli, M., Dharuri, H., Li, L., Sauro, H., Schilstra, M., Shapiro, B. E., Snoep, J. L. & Hucka, M., 2006, In : Nucleic Acids Research. 34, Supp 1, p. D689-691

CellML2SBML: conversion of CellML into SBML

Schilstra, M., Li, L., Matthews, J., Finney, A., Hucka, M. & Le Novere, N., 2006, In : Bioinformatics. 22, 8, p. 1018-1020

Evolutionary robustness of differentiation in genetic regulatory networks

Knabe, J., Nehaniv, C. L. & Schilstra, M., 2006, In: Explorations in the Complexity of Possible Life; Procs of the 7th German Workshop on Artificial Life (GWAL7). IOS Press, p. 75-84

Evolving biological clocks using genetic regulatory networks

Knabe, J., Nehaniv, C. L., Schilstra, M. & Quick, T., 2006, In: ARTIFICIAL LIFE X: PROCEEDINGS OF THE TENTH INTERNATIONAL CONFERENCE ON THE SIMULATION AND SYNTHESIS OF LIVING SYSTEMS, edited by Rocha, L.M.; Yaeger, L.S.; Bedau, M.A.; Floreano, D.; Goldstone, R.L.; Vespignani, A.. MIT Press, p. 15-21

Design of spatially extended neural networks for specific applications

Adams, R., te Boekhorst, R., Rust, A. G., Kaye, P. H. & Schilstra, M., 2004, Proceedings of the International Joint Conference on Neural Networks. IEEE, Vol. 4. p. 3101-3106

Evolving a Lingua Franca and Associated Software Infrastructure for Computational Systems Biology - the Systems Biology Markup Language (SBML) Project

Hucka, M., Finney, A., Bornstein, B., Keating, S., Shapiro, B. E., Matthews, J., Kovitz, B. L., Schilstra, M., Funahashi, A., Doyle, J. C. & Kitano, H., 2004, In : IEE Proceedings - Systems Biology. 1, 1, p. 41-53

A statistical approach to distinguish between different DNA functional parts

Abnizova, I., Schilstra, M., Te Boekhorst, R. & Nehaniv, C. L., 2003, In : WSEAS Transactions on Computers. 2, 4, p. 1180-1187

Evolving computational neural systems using synthetic developmental mechanisms

Adams, R. G., Rust, A. G., Schilstra, M. & Bolouri, H., 2003, On Growth, Form and Computers. Kumar, S. & Bentley, P. J. (eds.). Elsevier, p. 353-376

A Finite State Automation Model for Multi-Neuron Simulations

Schilstra, M., Rust, A. G., Adams, R. G. & Bolouri, H., 2002, In : Neurocomputing. 44, p. 1141-1148

A Genomic Regulatory Network for Development

Davidson, E. H., Rast, J. P., Oliveri, P., Ransick, A., Calestani, C., Yuh, C. H., Minokawa, T., Amore, G., Hinman, V., Arenas-Mena, C., Otim, A., Brown, C. T., Livi, C. B., Lee, P. Y., Revilla, R., Rust, A. G., Pan, Z., Schilstra, M., Clarke, P. J. C., Arnone, M. I. & 5 othersRowen, L., Cameron, R. A., McClay, D. R., Hood, L. & Bolouri, H., 2002, In : Science. 295, 5560, p. 1669-1678

A provisonal regulatory gene network for specification of endomesoderm in the sea urchin embryo

Davidson, E. H., Rast, J. P., Oliveri, P., Ransick, A., Calestani, C., Yuh, C. H., Minokawa, T., Amore, G., Hinman, V., Arenas-Mena, C., Otim, O., Brown, C. T., Livi, C. B., Lee, P. Y., Revilla, R., Schilstra, M., Clarke, P. J. C., Rust, A. G., Pan, Z., Arnone, M. I. & 5 othersRowen, L., Cameron, R. A., McClay, D. R., Hood, L. & Bolouri, H., 2002, In : Developmental Biology. 246, p. 162-190

New Computational Approaches for Analysis of cis-Regulatory Networks

Brown, C. T., Rust, A. G., Clarke, P. J. C., Pan, Z., Schilstra, M., De Buysscher, T., Griffin, G., Wold, B. J., Cameron, R. A., Davidson, E. H. & Bolouri, H., 2002, In : Developmental Biology. 246, p. 86-102

Replacement of Tyrosine D with Phenylalanine Affects the Normal Proton Transfer Pathways for the Reduction of P680+ in Oxygen-Evolving Photosystem II Particles from Chlamydomonas

Jeans, C., Schilstra, M., Ray, N., Husain, S., Minagawa, J., Nugent, J. & Klug, D. R., 2002, In : Biochemistry. 41, 52, p. 1574-15761

The Temperature Dependence of P680+ Reduction in Oxygen-Evolving Photosystem II

Jeans, C., Schilstra, M. & Klug, D. R., 2002, In : Biochemistry. 41, 15, p. 5015-5023

Are the trapping dynamics in Photosystem II sensitive to QA redox potential?

Barter, L., Schilstra, M., Barber, J., Durrant, J. R. & Klug, D. R., 2001, In : Journal of Photochemistry and Photobiology A: Chemistry. 142, 2-3, p. 127-132

Relationship between Excitation Energy Transfer, Trapping, and Antenna Size in Photosystem II

Barter, L., Bianchietti, M., Jeans, C., Schilstra, M., Hankamer, B., Diner, B. A., Barber, J., Durrant, J. R. & Klug, D. R., 2001, In : Biochemistry. 40, 13, p. 4026-4034

Similarity between electron donor side reactions in the solubilized Photosystem II–LHC II supercomplex and Photosystem-II-containing membranes

Schilstra, M., Nield, J., Dorner, W., Hankamer, B., Carradus, M., Barter, L., Barber, J. & Klug, D. R., 1999, In : Photosynthesis Research. 60, 2-3, p. 191-198

Modulation of Quantum Yield of Primary Radical Pair Formation in Photosystem II by Site-Directed Mutagenesis Affecting Radical Cations and Anions

Merry, S. A. P., Nixon, P. L., Barter, L., Schilstra, M., Porter, G., Barber, J., Durrant, J. R. & Klug, D. R., 1998, In : Biochemistry. 37, 50, p. 17439-17447

Proton/Hydrogen Transfer Affects the S-State-Dependent Microsecond Phases of P680+ Reduction during Water Splitting

Schilstra, M., Rappaport, F., Nugent, J., Barnett, C. J., Barber, J. & Klug, D. R., 1998, In : Biochemistry. 37, 11, p. 3974-3981

Mechanism of Lipoxygenase Inactivation by the Linoleic Acid Analogue Octadeca-9,12-diynoic Acid

Schilstra, M., Nieuwenhuizen, W. F., Veldink, G. A. & Vliegenthart, J. F. G., 1996, In : Biochemistry. 35, 11, p. 3396-3401

Changes in the Iron Coordination Sphere of Fe(II) Lipoxygenase-1 from Soybeans upon Binding of Linoleate or Oleate

Van Der Heijdt, L. M., Schilstra, M., Feiters, M. C., Navaratnam, S., Nolting, H-F., Hermes, C., Veldink, G. A. & Vliegenthart, J. F. G., 1995, In : European Journal of Biochemistry. 231, 1, p. 186-191

Fe(II1)-Lipoxygenase Converts Its Suicide-Type Inhibitor Octadeca-9,12-diynoic Acid into 1l -Oxooctadeca-9,12-diynoic Acid

Nieuwenhuizen, W. F., Schilstra, M., Van der Kerk, A., Brandsma, L., Veldink, G. A. & Vliegenthart, J. F. G., 1995, In : Biochemistry. 34, 33, p. 10538-10545

Substrates and products in lipoxygenase biocatalysis

Veldink, G. A., Nieuwenhuizen, W. F., Schilstra, M. & Vliegenthart, J. F. G., 1995, Proceedings of the Second SFB Symposium held in Wurzburg, September 21-23, 1994, edited by Werner, H.; Sundermeyer, J.. Friedrich Vieweg & Sons Verlagsgesellschaft mbH, p. 27-32

Effect of Nonionic Detergents on Lipoxygenase Catalysis

Schilstra, M., Veldink, G. A. & Vliegenthart, J. F. G., 1994, In : Lipids. 29, 4, p. 225-231

Effects of the Tubulin-Colchicine Complex on Microtubule Dynamic Instability

Vandecandelaere, A., Martin, S. R., Schilstra, M. & Bayley, P. M., 1994, In : Biochemistry. 33, 10, p. 2792-2801

The Dioxygenation Rate in Lipoxygenase Catalysis Is Determined by the Amount of Iron( HI) Lipoxygenase in Solution

Schilstra, M., Veldink, G. A. & Vliegenthart, J. F. G., 1994, In : Biochemistry. 33, 5, p. 3974-3979

Dynamic instability of microtubules: Monte Carlo simulation and application to different types of microtubule lattice

Martin, S. R., Schilstra, M. & Bayley, P. M., 1993, In : Biophysical Journal. 65, 2, p. 578-596

Kinetic analysis of the induction period in lipoxygenase catalysis

Schilstra, M., Veldink, G. A. & Vliegenthart, J. F. G., 1993, In : Biochemistry. 32, 30, p. 7686-7691

Effect of lipid hydroperoxide on lipoxygenase kinetics

Schilstra, M., Veldink, G. A., Verhagen, J. & Vliegenthart, J. F. G., 1992, In : Biochemistry. 31, 33, p. 7692-7699

Opposite-end behaviour of dynamic microtubules

Martin, S. R., Schilstra, M. & Bayley, P. M., 1991, In : BBA - General Subjects. 1073, 3, p. 555-561

The effect of solution composition on microtubule dynamic instability

Schilstra, M., Bayley, P. M. & Martin, S. R., 1991, In : Biochemical Journal. 277, 3, p. 839-847

Microtubule dynamic instability: numerical simulation of microtubule transition properties using a Lateral Cap model

Bayley, P. M., Schilstra, M. & Martin, S. R., 1990, In : Journal of Cell Science. 95, 1, p. 33-48

A Lateral Cap model of microtubule dynamic instability

Bayley, P. M., Schilstra, M. & Martin, S. R., 1989, In : FEBS Letters. 259, 1, p. 181-184

A simple formulation of microtubule dynamics: quantitative implications of the dynamic instability of microtubule

Bayley, P. M., Schilstra, M. & Martin, S. R., 1989, In : Journal of Cell Science. 93, 2, p. 241-254

The effect of podophyllotoxin on microtubule dynamics

Schilstra, M., Martin, S. R. & Bayley, P. M., 1989, In : Journal of Biological Chemistry. 264, 15, p. 8827-8834

Microtubule dynamics: experimental evidence and numerical modelling

Bayley, P. M., Gal, V., Karecla, P., Martin, S. R., Schilstra, M. & Engelborghs, Y., 1988, In : Springer Series in Biophysics. 3, p. 249-258

Dynamic properties of microtubules at steady state of polymerisation

Martin, S. R., Schilstra, M. & Bayley, P. M., 1987, In : Biochemical and Biophysical Research Communications. 149, 2, p. 461-467

On the relationship between nucleotide hydrolysis and microtubule assembly: Studies with a GTP-regenerating system

Schilstra, M., Martin, S. R. & Bayley, P. M., 1987, In : Biochemical and Biophysical Research Communications. 147, 2, p. 588-595

Three-dimensional image reconstruction of helical aggregates of trypsin modified elongation factor EF-Tu from Escherichia coli

Schilstra, M., Cremers, A. F. M., Bosch, L. & Mellema, J. E., 1986, In : Journal of Ultrastructure and Molecular Structure Research. 94, 3, p. 260-267

Immunocytochemical localization of the elongation factor Tu in E. coli cells

Schilstra, M., Slot, J. W., Van der Meide, P. H., Posthuma, G., Cremers, A. F. M. & Bosch, L., 1984, In : FEBS Letters. 165, 2, p. 175-179

Copper(I) and copper(II) compounds of 1,7-bis(2-benzimidazolyl)-2,6-dithiaheptane (BBDHp). X-ray structure of linearly coordinated copper(I) in the cation [CuI(BBDHp)]+

Schilstra, M., Birker, P. J. M. W. L., Verschoor, G. C. & Reedijk, J., 1982, In : Inorganic Chemistry. 21, 7, p. 2637-2644

An electron microscopic investigation of the structure of Alfalfa mosaic virus

Cremers, A. F. M., Oostergetel, G. T., Schilstra, M. & Mellema, J. E., 1980, In : Journal of Molecular Biology. 145, 3, p. 545-561

Low-dose electron image reconstruction of negatively stained contractile phage sheath from Bacillus subtilis (PBS-Z)

Cremers, A. F. M., Fischer, J. C., Schilstra, M. & Mellema, J. E., 1979, In : Ultramicroscopy. 4, 4, p. 395-412

Projects

Collaboration on DARPA proposal

Schilstra, M., Adams, R. & Keating, S.

£26,680.00, California Institute of Technology

1/03/0531/12/05

Development of Netbuilder

Nehaniv, C. & Schilstra, M.

£178,709.00, Wellcome Trust

1/03/0428/02/06

Model Sharing and Co-Simulation Standards for System

Schilstra, M. & Adams, R.

£171,032.00, Biotechnology and Biological Sciences Research Council

1/05/0230/04/04

Open philosophies for associative autopoietic ecosystems (OPAALS)

Nehaniv, C. & Schilstra, M.

£28,388.00, European Commission

1/07/0931/12/09