University of Hertfordshire

Dr Maria Schilstra

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Dr. Maria Schilstra

  • Centre for Computer Science and Informatics Research

Research output

Input-location dependent gain modulation in cerebellar nucleus neurons

Psarrou, M., Schilstra, M., Davey, N., Torben-Nielsen, B. & Steuber, V. 18 Aug 2016 In : BMC Neuroscience. 17, Supplement 1, 7

The role of cerebellar short-term synaptic plasticity in the pathology and medication of downbeat nystagmus

Goncharenko, J., Davey, N., Schilstra, M. & Steuber, V. 18 Aug 2016 In : BMC Neuroscience. 17, p. P51

Unravelling how βCaMKII controls the direction of plasticity at parallel fibre-Purkinje cell synapses

Pinto, T. M., Schilstra, M. J., Steuber, V. & Roque, A. C. 31 Dec 2015 International Conference of Computational Methods in Sciences and Engineering 2015, ICCMSE 2015. American Institute of Physics Inc., Vol. 1702, 130002

Symmetry structure in discrete models of biochemical systems: natural subsystems and the weak control hierarchy in a new model of computation driven by interactions

Nehaniv, C. L., Rhodes, J., Egri-Nagy, A., Dini, P., Rothstein Morris, E., Horvath, G., Karimi, F., Schreckling, D. & Schilstra, M. 28 Jul 2015 In : Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 373, 51 p., 20140223

βCaMKII regulates bidirectional long-term plasticity in cerebellar Purkinje cells by a CaMKII/PP2B switch mechanism

Matos Pinto, T., Schilstra, M., Steuber, V. & Roque, A. 21 Jul 2014 In : BMC Neuroscience. 15, Supp 1, p. P58 2 p.

Evolving spiking neural networks for temporal pattern recognition in the presence of noise

Abdelmotaleb, A., Davey, N., Schilstra, M., Steuber, V. & Wrobel, B. 2014 Artificial Life 2014: Procs of the Fourteenth International Conference on the Synthesis and Simulation of Living Systems. Sayama, H. (ed.). MIT Press, p. 965-972

Exploring the concept of interaction computing through the discrete algebraic analysis of the Belousov-Zhabotinsky reaction

Dini, P., Nehaniv, C. L., Egri-Nagy, A. & Schilstra, M. May 2013 In : Biosystems. 112, 2, p. 145-162 18 p.

Filamentous actin binding enables betaCaMKII to regulate bidirectional plasticity in cerebellar Purkinje cells

Pinto, T. M., Schilstra, M. & Steuber, V. 2013 In : BMC Neuroscience. 14, Supp 1, 2 p., P375

From evolving artificial gene regulatory networks to evolving spiking neural networks for pattern recognition

Abdelmotaleb, A., Schilstra, M., Davey, N., Steuber, V. & Wrobel, B. 2013 In : BMC Neuroscience. 14, Supp 1, 1 p., P423

A knowledge-based diagnostic clinical decision support system for musculoskeletal disorders of the shoulder for use in a primary care setting

Farmer, N. & Schilstra, M. 2012 In : Shoulder and Elbow. 4, 2, p. 141-151 11 p.

Algebraic analysis of the computation in the Belousov-Zhabotinsky reaction

Dini, P., Nehaniv, C. L., Egri-Nagy, A. & Schilstra, M. 2012 Information Processing in Cells and Tissues. Springer, p. 216-224 9 p. (Lecture Notes in Computer Science; vol. 7223)

BIOMICS Project: Biological and Mathematical Basis of Interaction Computing

Dini, P., Nehaniv, C. L., Egri-Nagy, A., Schilstra, M., Schreckling, D., Posegga, J., Horvath, G. & Munro, A. J. 2012 In : International Journal of Unconventional Computing. 8, 4, p. 283-287 5 p.

Does CamKII decode ca2+ oscillations?

Pinto, T. M., Schilstra, M. & Steuber, V. 2012 In : BMC Neuroscience. 13, Supp 1, 2 p., O15

The effective calcium/calmodulin concentration determines the sensitivity of CaMKII to the frequency of calcium oscillations

Pinto, T. M., Schilstra, M. & Steuber, V. 2012 Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 7223 LNCS, p. 131-135 5 p.

Genetic algorithms and their application to in silico evolution of genetic regulatory networks

Knabe, J., Wegner, K., Nehaniv, C. L. & Schilstra, M. 2010 In : Methods in Molecular Biology. 673, 1, p. 297-321

Stochastic model of template-directed elongation processes in biology

Schilstra, M. & Nehaniv, C. L. 2010 In : Biosystems. 102, 1, p. 55-60

Simple stochastic simulation

Schilstra, M. & Martin, S. R. 2009 Methods in Enzymology: Computer Methods. Elsevier, Vol. 467, p. 381-409

Do Motifs Reflect Evolved Function? – No Convergent Evolution of Genetic Regulatory Network Subgraph Topologies

Knabe, J., Nehaniv, C. L. & Schilstra, M. Oct 2008 In : Biosystems. 94, 1-2, p. 68-74

Automatic Analysis of Computation in BioChemical Reactions

Egri-Nagy, A., Nehaniv, C. L., Rhodes, J. L. & Schilstra, M. 2008 In : Biosystems. 94, 1-2, p. 126-134

Bio-logic: gene expression and the laws of combinatorial logic

Schilstra, M. & Nehaniv, C. L. 2008 In : Artificial Life. 14, 1, p. 121-133

Circular Dichroism and Its Application to the Study of Biomolecules

Martin, S. R. & Schilstra, M. 2008 In : Methods in Cell Biology. 84, p. 263-293

Evolution and morphogenesis of differentiated multicellular organisms: autonomously generated diffusion gradients for positional information

Knabe, J., Schilstra, M. & Nehaniv, C. L. 2008 Artificial Life XI: Procs of the 11th Int Conf on the Simulation and Synthesis of Living Systems.. MIT Press, p. 321-328

Genetic regulatory network models of biological clocks: evolutionary history matters

Knabe, J. F., Nehaniv, C. L. & Schilstra, M. 2008 In : Artificial Life. 14, 1, p. 135-148

Methods for Simulating the Dynamics of Complex Biological Processes

Schilstra, M., Martin, S. R. & Keating, S. 2008 In : Methods in Cell Biology. 84, p. 807-842

Rapid Kinetic Techniques

Eccleston, J. F., Martin, S. R. & Schilstra, M. 2008 In : Methods in Cell Biology. 84, p. 445-477

Regulation of gene regulation - smooth binding with dynamic affinity affects evolvability

Knabe, J., Nehaniv, C. L. & Schilstra, M. 2008 IEEE Congress on Evolutionary Computation, CEC 2008. IEEE, p. 890-896

SBML models and MathSBML

Shapiro, B. E., Finney, A., Hucka, M., Bornstein, B., Funahashi, A., Jouraku, A., Keating, S., Le Novere, N., Matthews, J. & Schilstra, M. 2007 Introduction to Systems Biology. Choi, S. (ed.). Human Press / Springer, p. 395-421

The Essential Motif that wasn't there: Topological and Lesioning Analysis of Evolved Genetic Regulatory Networks

Knabe, J., Nehaniv, C. L. & Schilstra, M. 2007 In: IEEE Symposium on Artificial Life, ALIFE'07. IEEE, p. 69-76

The NetBuilder project: development of a tool for constructing, simulating, evolving, and analysing complex regulatory networks

Wegner, K., Knabe, J., Robinson, M., Egri-Nagy, A. & Schilstra, M. 2007 In : BMC Systems Biology. 1, Suppl 1

An elastically tethered viscous load imposes a regular gait on the motion of myosin-V. Simulation of the effect of transient force relaxation on a stochastic process

Schilstra, M. & Martin, S. R. 2006 In : Journal of The Royal Society Interface. 3, 6, p. 153-165

BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems

Le Novere, N., Bornstein, B., Broicher, A., Courtot, M., Donizelli, M., Dharuri, H., Li, L., Sauro, H., Schilstra, M., Shapiro, B. E., Snoep, J. L. & Hucka, M. 2006 In : Nucleic Acids Research. 34, Supp 1, p. D689-691

CellML2SBML: conversion of CellML into SBML

Schilstra, M., Li, L., Matthews, J., Finney, A., Hucka, M. & Le Novere, N. 2006 In : Bioinformatics. 22, 8, p. 1018-1020

Evolutionary robustness of differentiation in genetic regulatory networks

Knabe, J., Nehaniv, C. L. & Schilstra, M. 2006 In: Explorations in the Complexity of Possible Life; Procs of the 7th German Workshop on Artificial Life (GWAL7). IOS Press, p. 75-84

Evolving biological clocks using genetic regulatory networks

Knabe, J., Nehaniv, C. L., Schilstra, M. & Quick, T. 2006 In: ARTIFICIAL LIFE X: PROCEEDINGS OF THE TENTH INTERNATIONAL CONFERENCE ON THE SIMULATION AND SYNTHESIS OF LIVING SYSTEMS, edited by Rocha, L.M.; Yaeger, L.S.; Bedau, M.A.; Floreano, D.; Goldstone, R.L.; Vespignani, A.. MIT Press, p. 15-21

Design of spatially extended neural networks for specific applications

Adams, R., te Boekhorst, R., Rust, A. G., Kaye, P. H. & Schilstra, M. 2004 Proceedings of the International Joint Conference on Neural Networks. IEEE, Vol. 4, p. 3101-3106

Evolving a Lingua Franca and Associated Software Infrastructure for Computational Systems Biology - the Systems Biology Markup Language (SBML) Project

Hucka, M., Finney, A., Bornstein, B., Keating, S., Shapiro, B. E., Matthews, J., Kovitz, B. L., Schilstra, M., Funahashi, A., Doyle, J. C. & Kitano, H. 2004 In : IEE Proceedings - Systems Biology. 1, 1, p. 41-53

A statistical approach to distinguish between different DNA functional parts

Abnizova, I., Schilstra, M., Te Boekhorst, R. & Nehaniv, C. L. 2003 In : WSEAS Transactions on Computers. 2, 4, p. 1180-1187

Evolving computational neural systems using synthetic developmental mechanisms

Adams, R. G., Rust, A. G., Schilstra, M. & Bolouri, H. 2003 On Growth, Form and Computers. Kumar, S. & Bentley, P. J. (eds.). Elsevier, p. 353-376

A Finite State Automation Model for Multi-Neuron Simulations

Schilstra, M., Rust, A. G., Adams, R. G. & Bolouri, H. 2002 In : Neurocomputing. 44, p. 1141-1148

A Genomic Regulatory Network for Development

Schilstra, M. & 24 others Davidson, E. H., Rast, J. P., Oliveri, P., Ransick, A., Calestani, C., Yuh, C. H., Minokawa, T., Amore, G., Hinman, V., Arenas-Mena, C., Otim, A., Brown, C. T., Livi, C. B., Lee, P. Y., Revilla, R., Rust, A. G., Pan, Z., Clarke, P. J. C., Arnone, M. I., Rowen, L., Cameron, R. A., McClay, D. R., Hood, L. & Bolouri, H. 2002 In : Science. 295, 5560, p. 1669-1678

A provisonal regulatory gene network for specification of endomesoderm in the sea urchin embryo

Schilstra, M. & 24 others Davidson, E. H., Rast, J. P., Oliveri, P., Ransick, A., Calestani, C., Yuh, C. H., Minokawa, T., Amore, G., Hinman, V., Arenas-Mena, C., Otim, O., Brown, C. T., Livi, C. B., Lee, P. Y., Revilla, R., Clarke, P. J. C., Rust, A. G., Pan, Z., Arnone, M. I., Rowen, L., Cameron, R. A., McClay, D. R., Hood, L. & Bolouri, H. 2002 In : Developmental Biology. 246, p. 162-190

New Computational Approaches for Analysis of cis-Regulatory Networks

Brown, C. T., Rust, A. G., Clarke, P. J. C., Pan, Z., Schilstra, M., De Buysscher, T., Griffin, G., Wold, B. J., Cameron, R. A., Davidson, E. H. & Bolouri, H. 2002 In : Developmental Biology. 246, p. 86-102

Replacement of Tyrosine D with Phenylalanine Affects the Normal Proton Transfer Pathways for the Reduction of P680+ in Oxygen-Evolving Photosystem II Particles from Chlamydomonas

Jeans, C., Schilstra, M., Ray, N., Husain, S., Minagawa, J., Nugent, J. & Klug, D. R. 2002 In : Biochemistry. 41, 52, p. 1574-15761

The Temperature Dependence of P680+ Reduction in Oxygen-Evolving Photosystem II

Jeans, C., Schilstra, M. & Klug, D. R. 2002 In : Biochemistry. 41, 15, p. 5015-5023

Are the trapping dynamics in Photosystem II sensitive to QA redox potential?

Barter, L., Schilstra, M., Barber, J., Durrant, J. R. & Klug, D. R. 2001 In : Journal of Photochemistry and Photobiology A: Chemistry. 142, 2-3, p. 127-132

Relationship between Excitation Energy Transfer, Trapping, and Antenna Size in Photosystem II

Barter, L., Bianchietti, M., Jeans, C., Schilstra, M., Hankamer, B., Diner, B. A., Barber, J., Durrant, J. R. & Klug, D. R. 2001 In : Biochemistry. 40, 13, p. 4026-4034

Similarity between electron donor side reactions in the solubilized Photosystem II–LHC II supercomplex and Photosystem-II-containing membranes

Schilstra, M., Nield, J., Dorner, W., Hankamer, B., Carradus, M., Barter, L., Barber, J. & Klug, D. R. 1999 In : Photosynthesis Research. 60, 2-3, p. 191-198

Modulation of Quantum Yield of Primary Radical Pair Formation in Photosystem II by Site-Directed Mutagenesis Affecting Radical Cations and Anions

Merry, S. A. P., Nixon, P. L., Barter, L., Schilstra, M., Porter, G., Barber, J., Durrant, J. R. & Klug, D. R. 1998 In : Biochemistry. 37, 50, p. 17439-17447

Proton/Hydrogen Transfer Affects the S-State-Dependent Microsecond Phases of P680+ Reduction during Water Splitting

Schilstra, M., Rappaport, F., Nugent, J., Barnett, C. J., Barber, J. & Klug, D. R. 1998 In : Biochemistry. 37, 11, p. 3974-3981

Mechanism of Lipoxygenase Inactivation by the Linoleic Acid Analogue Octadeca-9,12-diynoic Acid

Schilstra, M., Nieuwenhuizen, W. F., Veldink, G. A. & Vliegenthart, J. F. G. 1996 In : Biochemistry. 35, 11, p. 3396-3401

Changes in the Iron Coordination Sphere of Fe(II) Lipoxygenase-1 from Soybeans upon Binding of Linoleate or Oleate

Van Der Heijdt, L. M., Schilstra, M., Feiters, M. C., Navaratnam, S., Nolting, H-F., Hermes, C., Veldink, G. A. & Vliegenthart, J. F. G. 1995 In : European Journal of Biochemistry. 231, 1, p. 186-191

Fe(II1)-Lipoxygenase Converts Its Suicide-Type Inhibitor Octadeca-9,12-diynoic Acid into 1l -Oxooctadeca-9,12-diynoic Acid

Nieuwenhuizen, W. F., Schilstra, M., Van der Kerk, A., Brandsma, L., Veldink, G. A. & Vliegenthart, J. F. G. 1995 In : Biochemistry. 34, 33, p. 10538-10545

Substrates and products in lipoxygenase biocatalysis

Veldink, G. A., Nieuwenhuizen, W. F., Schilstra, M. & Vliegenthart, J. F. G. 1995 Proceedings of the Second SFB Symposium held in Wurzburg, September 21-23, 1994, edited by Werner, H.; Sundermeyer, J.. Friedrich Vieweg & Sons Verlagsgesellschaft mbH, p. 27-32

Effect of Nonionic Detergents on Lipoxygenase Catalysis

Schilstra, M., Veldink, G. A. & Vliegenthart, J. F. G. 1994 In : Lipids. 29, 4, p. 225-231

Effects of the Tubulin-Colchicine Complex on Microtubule Dynamic Instability

Vandecandelaere, A., Martin, S. R., Schilstra, M. & Bayley, P. M. 1994 In : Biochemistry. 33, 10, p. 2792-2801

The Dioxygenation Rate in Lipoxygenase Catalysis Is Determined by the Amount of Iron( HI) Lipoxygenase in Solution

Schilstra, M., Veldink, G. A. & Vliegenthart, J. F. G. 1994 In : Biochemistry. 33, 5, p. 3974-3979

Dynamic instability of microtubules: Monte Carlo simulation and application to different types of microtubule lattice

Martin, S. R., Schilstra, M. & Bayley, P. M. 1993 In : Biophysical Journal. 65, 2, p. 578-596

Kinetic analysis of the induction period in lipoxygenase catalysis

Schilstra, M., Veldink, G. A. & Vliegenthart, J. F. G. 1993 In : Biochemistry. 32, 30, p. 7686-7691

Effect of lipid hydroperoxide on lipoxygenase kinetics

Schilstra, M., Veldink, G. A., Verhagen, J. & Vliegenthart, J. F. G. 1992 In : Biochemistry. 31, 33, p. 7692-7699

Opposite-end behaviour of dynamic microtubules

Martin, S. R., Schilstra, M. & Bayley, P. M. 1991 In : BBA - General Subjects. 1073, 3, p. 555-561

The effect of solution composition on microtubule dynamic instability

Schilstra, M., Bayley, P. M. & Martin, S. R. 1991 In : Biochemical Journal. 277, 3, p. 839-847

Microtubule dynamic instability: numerical simulation of microtubule transition properties using a Lateral Cap model

Bayley, P. M., Schilstra, M. & Martin, S. R. 1990 In : Journal of Cell Science. 95, 1, p. 33-48

A Lateral Cap model of microtubule dynamic instability

Bayley, P. M., Schilstra, M. & Martin, S. R. 1989 In : FEBS Letters. 259, 1, p. 181-184

A simple formulation of microtubule dynamics: quantitative implications of the dynamic instability of microtubule

Bayley, P. M., Schilstra, M. & Martin, S. R. 1989 In : Journal of Cell Science. 93, 2, p. 241-254

The effect of podophyllotoxin on microtubule dynamics

Schilstra, M., Martin, S. R. & Bayley, P. M. 1989 In : Journal of Biological Chemistry. 264, 15, p. 8827-8834

Microtubule dynamics: experimental evidence and numerical modelling

Bayley, P. M., Gal, V., Karecla, P., Martin, S. R., Schilstra, M. & Engelborghs, Y. 1988 In : Springer Series in Biophysics. 3, p. 249-258

Dynamic properties of microtubules at steady state of polymerisation

Martin, S. R., Schilstra, M. & Bayley, P. M. 1987 In : Biochemical and Biophysical Research Communications. 149, 2, p. 461-467

On the relationship between nucleotide hydrolysis and microtubule assembly: Studies with a GTP-regenerating system

Schilstra, M., Martin, S. R. & Bayley, P. M. 1987 In : Biochemical and Biophysical Research Communications. 147, 2, p. 588-595

Three-dimensional image reconstruction of helical aggregates of trypsin modified elongation factor EF-Tu from Escherichia coli

Schilstra, M., Cremers, A. F. M., Bosch, L. & Mellema, J. E. 1986 In : Journal of Ultrastructure and Molecular Structure Research. 94, 3, p. 260-267

Immunocytochemical localization of the elongation factor Tu in E. coli cells

Schilstra, M., Slot, J. W., Van der Meide, P. H., Posthuma, G., Cremers, A. F. M. & Bosch, L. 1984 In : FEBS Letters. 165, 2, p. 175-179

Copper(I) and copper(II) compounds of 1,7-bis(2-benzimidazolyl)-2,6-dithiaheptane (BBDHp). X-ray structure of linearly coordinated copper(I) in the cation [CuI(BBDHp)]+

Schilstra, M., Birker, P. J. M. W. L., Verschoor, G. C. & Reedijk, J. 1982 In : Inorganic Chemistry. 21, 7, p. 2637-2644

An electron microscopic investigation of the structure of Alfalfa mosaic virus

Cremers, A. F. M., Oostergetel, G. T., Schilstra, M. & Mellema, J. E. 1980 In : Journal of Molecular Biology. 145, 3, p. 545-561

Low-dose electron image reconstruction of negatively stained contractile phage sheath from Bacillus subtilis (PBS-Z)

Cremers, A. F. M., Fischer, J. C., Schilstra, M. & Mellema, J. E. 1979 In : Ultramicroscopy. 4, 4, p. 395-412

Projects

Collaboration on DARPA proposal

Schilstra, M. & Adams, R.

1/03/0531/12/05

£26,680, California Institute of Technology

Development of Netbuilder

Nehaniv, C. & Schilstra, M.

1/03/0428/02/06

£178,709, Wellcome Trust

Model Sharing & Co-Simulation Standards for System

Schilstra, M. & Adams, R.

1/05/0230/04/04

£171,032, Biotechnology and Biological Sciences Research Council

Open philosophies for associative autopoietic ecosystems (OPAALS)

Nehaniv, C. & Schilstra, M.

1/07/0931/12/09

£28,388, European Commission