University of Hertfordshire

Dr Philip Sawle B.Sc (Hons)

Philip Sawle

Dr Philip Sawle B.Sc (Hons)

Postal address:
University of Hertfordshire, Hatfield, Hertfordshire
United Kingdom

Publications

  1. 2015
  2. Clinical, structural, biochemical and X-ray crystallographic correlates of pathogenicity for variants in the C-propeptide region of the COL3A1 gene

    Stembridge, N. S., Vandersteen, A. M., Ghali, N., Sawle, P., Nesbitt, M., Pollitt, R. C., Ferguson, D. J. P., Holden, S., Elmslie, F., Henderson, A., Hulmes, D. J. S. & Pope, F. M., Aug 2015, In : American journal of medical genetics. Part A. 167A, 8, p. 1763-72 10 p.

    Research output: Contribution to journalArticle

  3. 2014
  4. Four patients with Sillence type I osteogenesis imperfecta and mild bone fragility, complicated by left ventricular cardiac valvular disease and cardiac tissue fragility caused by type I collagen mutations

    Vandersteen, A. M., Lund, A. M., Ferguson, D. J. P., Sawle, P., Pollitt, R. C., Holder, S. E., Wakeling, E., Moat, N. & Pope, F. M., Feb 2014, In : American journal of medical genetics. Part A. 164A, 2, p. 386-91 6 p.

    Research output: Contribution to journalArticle

  5. 2013
  6. Vasorelaxing effects and inhibition of nitric oxide in macrophages by new iron-containing carbon monoxide-releasing molecules (CO-RMs)

    Motterlini, R., Sawle, P., Hammad, J., Mann, B. E., Johnson, T. R., Green, C. J. & Foresti, R., Feb 2013, In : Pharmacological Research. 68, 1, p. 108-17 10 p.

    Research output: Contribution to journalArticle

  7. 2012
  8. CORM-3, a carbon monoxide-releasing molecule, alters the inflammatory response and reduces brain damage in a rat model of hemorrhagic stroke

    Yabluchanskiy, A., Sawle, P., Homer-Vanniasinkam, S., Green, C. J., Foresti, R. & Motterlini, R., Feb 2012, In : Critical Care Medicine. 40, 2, p. 544-52 9 p.

    Research output: Contribution to journalArticle

  9. 2011
  10. A re-investigation of [Fe(L-cysteinate)2(CO)2]2-: an example of non-heme CO coordination of possible relevance to CO binding to ion channel receptors

    Hewison, L., Johnson, T. R., Mann, B. E., Meijer, A. J. H. M., Sawle, P. & Motterlini, R., 7 Sep 2011, In : Dalton Transactions. 40, 33, p. 8328-34 7 p.

    Research output: Contribution to journalArticle

  11. Modification of the deoxy-myoglobin/carbonmonoxy-myoglobin UV-vis assay for reliable determination of CO-release rates from organometallic carbonyl complexes

    Atkin, A. J., Lynam, J. M., Moulton, B. E., Sawle, P., Motterlini, R., Boyle, N. M., Pryce, M. T. & Fairlamb, I. J. S., 7 Jun 2011, In : Dalton Transactions. 40, 21, p. 5755-61 7 p.

    Research output: Contribution to journalArticle

  12. [Mn(CO)4{S2CNMe(CH2CO2H)}], a new water-soluble CO-releasing molecule

    Crook, S. H., Mann, B. E., Meijer, A. J. H. M., Adams, H., Sawle, P., Scapens, D. & Motterlini, R., 28 Apr 2011, In : Dalton Transactions. 40, 16, p. 4230-5 6 p.

    Research output: Contribution to journalArticle

  13. 2010
  14. Relationship between leukocyte kinetics and behavioral tests changes in the inflammatory process of hemorrhagic stroke recovery

    Yabluchanskiy, A., Sawle, P., Homer-Vanniasinkam, S., Green, C. J. & Motterlini, R., Dec 2010, In : Nature Neuroscience. 120, 12, p. 765-73 9 p.

    Research output: Contribution to journalArticle

  15. Iron indenyl carbonyl compounds: CO-releasing molecules

    Hewison, L., Crook, S. H., Johnson, T. R., Mann, B. E., Adams, H., Plant, S. E., Sawle, P. & Motterlini, R., 14 Oct 2010, In : Dalton Transactions. 39, 38, p. 8967-75 9 p.

    Research output: Contribution to journalArticle

  16. 2009
  17. Donor HO-1 expression inhibits intimal hyperplasia in unmanipulated graft recipients: a potential role for CD8+ T-cell modulation by carbon monoxide

    Clarke, H. M., Shrivastava, S., Motterlini, R., Sawle, P., Chen, D. & Dorling, A., 15 Sep 2009, In : Cell Transplantation. 88, 5, p. 653-61 9 p.

    Research output: Contribution to journalArticle

  18. Mu2-alkyne dicobalt(0)hexacarbonyl complexes as carbon monoxide-releasing molecules (CO-RMs): probing the release mechanism

    Atkin, A. J., Williams, S., Sawle, P., Motterlini, R., Lynam, J. M. & Fairlamb, I. J. S., 21 May 2009, In : Dalton Transactions. 19, p. 3653-6 4 p.

    Research output: Contribution to journalArticle

  19. 2008
  20. Structure-activity relationships of methoxychalcones as inducers of heme oxygenase-1

    Sawle, P., Moulton, B. E., Jarzykowska, M., Green, C. J., Foresti, R., Fairlamb, I. J. S. & Motterlini, R., Jul 2008, In : Chemical Research in Toxicology. 21, 7, p. 1484-94 11 p.

    Research output: Contribution to journalArticle

  21. 2007
  22. [(Eta-C5H4R)Fe(CO)2X], X = Cl, Br, I, NO3, CO2Me and [(eta-C5H4R)Fe(CO)3]+, R = (CH2)nCO2Me (n = 0-2), and CO2CH2CH2OH: a new group of CO-releasing molecules

    Scapens, D., Adams, H., Johnson, T. R., Mann, B. E., Sawle, P., Aqil, R., Perrior, T. & Motterlini, R., 21 Nov 2007, In : Dalton Transactions. 43, p. 4962-73 12 p.

    Research output: Contribution to journalArticle

  23. Eta(1)-2-pyrone metal carbonyl complexes as CO-releasing molecules (CO-RMs): a delicate balance between stability and CO liberation

    Fairlamb, I. J. S., Lynam, J. M., Moulton, B. E., Taylor, I. E., Duhme-Klair, A. K., Sawle, P. & Motterlini, R., 7 Sep 2007, In : Dalton Transactions. 33, p. 3603-5 3 p.

    Research output: Contribution to journalArticle

  24. 2006
  25. Bioactive properties of iron-containing carbon monoxide-releasing molecules

    Sawle, P., Hammad, J., Fairlamb, I. J. S., Moulton, B., O'Brien, C. T., Lynam, J. M., Duhme-Klair, A. K., Foresti, R. & Motterlini, R., Jul 2006, In : Journal of Pharmacology and Experimental Therapeutics. 318, 1, p. 403-10 8 p.

    Research output: Contribution to journalArticle

  26. Eta4-pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs)

    Fairlamb, I. J. S., Duhme-Klair, A-K., Lynam, J. M., Moulton, B. E., O'Brien, C. T., Sawle, P., Hammad, J. & Motterlini, R., 15 Feb 2006, In : Bioorganic & Medicinal Chemistry Letters. 16, 4, p. 995-8 4 p.

    Research output: Contribution to journalArticle

  27. 2005
  28. Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages

    Sawle, P., Foresti, R., Mann, B. E., Johnson, T. R., Green, C. J. & Motterlini, R., Jul 2005, In : British Journal of Pharmacology. 145, 6, p. 800-10 11 p.

    Research output: Contribution to journalArticle

  29. CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule

    Motterlini, R., Sawle, P., Hammad, J., Bains, S., Alberto, R., Foresti, R. & Green, C. J., Feb 2005, In : FASEB Journal. 19, 2, p. 284-6 3 p.

    Research output: Contribution to journalArticle

  30. 2001
  31. Homocysteine attenuates endothelial haem oxygenase-1 induction by nitric oxide (NO) and hypoxia

    Sawle, P., Foresti, R., Green, C. J. & Motterlini, R., 23 Nov 2001, In : FEBS Letters. 508, 3, p. 403-6 4 p.

    Research output: Contribution to journalArticle