University of Hertfordshire

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Resveratrol is one of a number of plant defence compounds produced in grapes and other plants, which is of interest because of its anti-inflammatory and cardioprotective properties. Many natural resveratrol analogues and synthetic analogues have also shown anticancer properties. The analogue arachidin-1, produced by peanuts, has been shown to have superior activity in preventing the expression of the inflammatory COX-2 enzyme. This project aims to develop a high-yielding synthesis of arachidin-1, as well as investigating novel synthetic analogues, which will be tested for their anti-inflammatory and anticancer properties.

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