University of Hertfordshire

14C Autoradiography with a novel wafer scale CMOS Active Pixel Sensor

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14C Autoradiography with a novel wafer scale CMOS Active Pixel Sensor. / Esposito, M.; Anaxagoras, T.; Larner, Joanne; Allinson, N.M.; Wells, K.

In: Journal of Instrumentation, Vol. 8, C01001, 07.01.2013.

Research output: Contribution to journalArticle

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Esposito, M. ; Anaxagoras, T. ; Larner, Joanne ; Allinson, N.M. ; Wells, K. / 14C Autoradiography with a novel wafer scale CMOS Active Pixel Sensor. In: Journal of Instrumentation. 2013 ; Vol. 8.

Bibtex

@article{ee494ea4b15b48beb0ea4683eb42d544,
title = "14C Autoradiography with a novel wafer scale CMOS Active Pixel Sensor",
abstract = "14C autoradiography is a well established technique for structural and metabolic analysis of cells and tissues. The most common detection medium for this application is film emulsion, which offers unbeatable spatial resolution due to its fine granularity but at the same time has some limiting drawbacks such as poor linearity and rapid saturation. In recent years several digital detectors have been developed, following the technological transition from analog to digital-based detection systems in the medical and biological field. Even so such digital systems have been greatly limited by the size of their active area (a few square centimeters), which have made them unsuitable for routine use in many biological applications where sample areas are typically ∼ 10– 100 cm2 . The Multidimensional Integrated Intelligent Imaging (MI3-Plus) consortium has recently developed a new large area CMOS Active Pixel Sensor (12.8cm × 13.1 cm). This detector, based on the use of two different pixel resolutions, is capable of providing simultaneously low noise and high dynamic range on a wafer scale. In this paper we will demonstrate the suitability of this detector for routine beta autoradiography in a comparative approach with widely used film emulsion.",
author = "M. Esposito and T. Anaxagoras and Joanne Larner and N.M. Allinson and K. Wells",
year = "2013",
month = "1",
day = "7",
doi = "10.1088/1748-0221/8/01/C01011",
language = "English",
volume = "8",
journal = "Journal of Instrumentation",
issn = "1748-0221",
publisher = "IOP Publishing Ltd.",

}

RIS

TY - JOUR

T1 - 14C Autoradiography with a novel wafer scale CMOS Active Pixel Sensor

AU - Esposito, M.

AU - Anaxagoras, T.

AU - Larner, Joanne

AU - Allinson, N.M.

AU - Wells, K.

PY - 2013/1/7

Y1 - 2013/1/7

N2 - 14C autoradiography is a well established technique for structural and metabolic analysis of cells and tissues. The most common detection medium for this application is film emulsion, which offers unbeatable spatial resolution due to its fine granularity but at the same time has some limiting drawbacks such as poor linearity and rapid saturation. In recent years several digital detectors have been developed, following the technological transition from analog to digital-based detection systems in the medical and biological field. Even so such digital systems have been greatly limited by the size of their active area (a few square centimeters), which have made them unsuitable for routine use in many biological applications where sample areas are typically ∼ 10– 100 cm2 . The Multidimensional Integrated Intelligent Imaging (MI3-Plus) consortium has recently developed a new large area CMOS Active Pixel Sensor (12.8cm × 13.1 cm). This detector, based on the use of two different pixel resolutions, is capable of providing simultaneously low noise and high dynamic range on a wafer scale. In this paper we will demonstrate the suitability of this detector for routine beta autoradiography in a comparative approach with widely used film emulsion.

AB - 14C autoradiography is a well established technique for structural and metabolic analysis of cells and tissues. The most common detection medium for this application is film emulsion, which offers unbeatable spatial resolution due to its fine granularity but at the same time has some limiting drawbacks such as poor linearity and rapid saturation. In recent years several digital detectors have been developed, following the technological transition from analog to digital-based detection systems in the medical and biological field. Even so such digital systems have been greatly limited by the size of their active area (a few square centimeters), which have made them unsuitable for routine use in many biological applications where sample areas are typically ∼ 10– 100 cm2 . The Multidimensional Integrated Intelligent Imaging (MI3-Plus) consortium has recently developed a new large area CMOS Active Pixel Sensor (12.8cm × 13.1 cm). This detector, based on the use of two different pixel resolutions, is capable of providing simultaneously low noise and high dynamic range on a wafer scale. In this paper we will demonstrate the suitability of this detector for routine beta autoradiography in a comparative approach with widely used film emulsion.

U2 - 10.1088/1748-0221/8/01/C01011

DO - 10.1088/1748-0221/8/01/C01011

M3 - Article

VL - 8

JO - Journal of Instrumentation

JF - Journal of Instrumentation

SN - 1748-0221

M1 - C01001

ER -