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Original languageEnglish
Pages (from-to)586-594
JournalInternational Journal of Pharmaceutics
Volume528
Issue1-2
Early online date15 Jun 2017
DOIs
Publication statusPublished - 7 Aug 2017

Abstract

Mucosa-mimetic materials are synthetic substrates which aim to replace animal tissue in mucoadhesion experiments. One potential mucosa-mimetic material is a hydrogel comprised of N-acryloyl-d-glucosamine and 2-hydroxyethylmethacrylate, which has been investigated as a surrogate for animal mucosae in the mucoadhesion testing of tablets and solution formulations. This study aims to investigate the efficacy of this mucosa-mimetic material in the testing of thermogelling semi-solid formulations, which transition from solution to gel upon warming. Two methods for assessing mucoadhesion have been used; tensile testing and a flow-through system, which allow for investigation under dramatically different conditions. It was found that the mucosa-mimetic material was a good surrogate for buccal mucosa using both testing methods. This material may be used to replace animal tissue in these experiments, potentially reducing the number of laboratory animals used in studies of this type.

Notes

This document is the Accepted Manuscript version of the following article: Jessica Bassi da Silva, Vitaliy V. Khutoryanskiy, Marcos L. Bruschi, and Michael T. Cook, ‘A mucosa-mimetic material for the mucoadhesion testing of thermogelling semi-solids’, International Journal of Pharmaceutics, vol. 528 (1-2): 586-594, August 2017. Under embargo. Embargo end date: 15 June 2018. © 2017 Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.

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