University of Hertfordshire

  • M.J. Ingram
  • E. Zeller
  • G.P. Moss
  • C.E. Hall
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Original languageEnglish
Pages (from-to)258-261
JournalEuropean Journal of Contraception and Reproductive Healthcare
Publication statusPublished - 2006


We report the synthesis of novel ester derivatives of nonoxynol-9, an approved spermicidal agent, using the non-steroidal inflammatory drugs (NSAIDs) ibuprofen and indomethacin. Indomethacin has previously been shown to inhibit the implantation of the fertilised ovum into the uterus wall of pregnant rats. It is proposed that nonoxynol-9, in combination with a non-selective NSAID may exhibit both anti-implantation and spermicidal properties.

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Original article can be found at: Copyright Informa. [Full text of this article is not available in the UHRA]

ID: 185500