University of Hertfordshire

Advances in oral transmucosal drug delivery

Research output: Contribution to journalLiterature review

Documents

  • 905436

    Accepted author manuscript, 619 KB, PDF document

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Original languageEnglish
Number of pages11
Pages (from-to)106-116
JournalJournal of Controlled Release
Journal publication date30 Jul 2011
Volume153
Issue2
DOIs
Publication statusPublished - 30 Jul 2011

Abstract

The successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity. Oral transmucosal delivery, especially buccal and sublingual delivery, has progressed far beyond the use of traditional dosage forms with novel approaches emerging continuously. This review highlights the physiological challenges as well as the advances and opportunities for buccal/sublingual drug delivery. Particular attention is given to new approaches which can extend dosage form retention time or can be engineered to deliver complex molecules such as proteins and peptides. The review will also discuss the physiology and local environment of the oral cavity in vivo and how this relates to the performance of transmucosal delivery systems.

Notes

Original article can be found at : http://sciencedirect.com/ Copyright Elsevier

ID: 308466