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Original languageEnglish
Article number258P
JournalpA2 online
Journal publication date2015
Volume21
Issue3
Publication statusPublished - 2015
EventPharmacology 2014 (BPS Meeting) - London, United Kingdom
Duration: 16 Dec 201418 Dec 2014

Abstract

Ageing has a profound effect upon gastrointestinal function through mechanisms that are poorly understood (1). A feature of ageing is impaired sensory perception, including a diminished sensory response to inflammatory evoked gastrointestinal injury (2). Since nociception is a key consequence of disease or tissue injury, triggering neurogenic inflammation and pain behaviour, its attenuation with age has consequences for disease progression and seeking medical advice (3). However, surprisingly little is known about the mechanisms contributing towards the age-associated blunting of sensory perception. In this current study we investigated the effect of ageing upon colonic sensory signalling pathways in order to address this question.

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Proceedings of the British Pharmacological Society at http://www.pA2online.org/abstracts/Vol12Issue3abst258P.pdf © 2016 pA2 Online ISSN 1741-1157

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