University of Hertfordshire

From the same journal

From the same journal

By the same authors

Age-mediated changes in the gastrointestinal tract

Research output: Contribution to journalArticle

Documents

  • Hamid Merchant
  • Fang Liu
  • Mine Orlu Gul
  • Abdul Basit
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Original languageEnglish
Number of pages14
Pages (from-to)382-395
JournalInternational Journal of Pharmaceutics
Journal publication date30 Oct 2016
Volume512
Issue2
Early online date13 Apr 2016
DOIs
Publication statusPublished - 30 Oct 2016

Abstract

Physiological functions of the two extreme ends of the age spectrum, children (<18 y old) and older adults (aged 65 y and over), differ from healthy young adults. This consequently affects the pharmacokinetic profiles of administered drugs, which, in turn, impacts upon clinical practice and drug therapy. The gastrointestinal milieu acts as a distinct and vital organ regulating the dissolution, absorption and metabolism of orally ingested drugs. Age-mediated alteration in the physiology and function of the gut can reshape the pharmacokinetics of certain drugs. However, our understanding of this topic is limited. This article references the gut physiology of healthy adults to capture the available evidence in the literature on the extent and nature of the changes in childhood and older age. The gut, as an organ, is examined with regards to the effect of age on luminal fluid, microbiota, transit and motility, and the intestinal mucosa. Whilst drastic developmental changes were observed in certain aspects of the gastrointestinal environment, the examination reveals significant gaps in our knowledge in the physiology and function of the developing or ageing gut. The revelation of the unknown paves the way towards a better characterization of the human gastrointestinal tract for optimized drug therapy in children and older adults.

Notes

This document is the accepted manuscript version for the following article, "Hamid A. Merchant, et al., “Age-mediated changes in the gastrointestinal tract”, International Journal of Pharmaceutics, Vol. 512(2): 382-395, April 2016." The final published version is available at: https://doi.org/10.1016/j.ijpharm.2016.04.024 Copyright © 2016, Elsevier.

ID: 11090486