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Age-mediated changes in the gastrointestinal tract

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Age-mediated changes in the gastrointestinal tract. / Merchant, Hamid; Liu, Fang; Orlu Gul, Mine ; Basit, Abdul.

In: International Journal of Pharmaceutics, Vol. 512, No. 2, 30.10.2016, p. 382-395.

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Merchant, Hamid ; Liu, Fang ; Orlu Gul, Mine ; Basit, Abdul. / Age-mediated changes in the gastrointestinal tract. In: International Journal of Pharmaceutics. 2016 ; Vol. 512, No. 2. pp. 382-395.

Bibtex

@article{6c84009569574a8f981547e9ba9e2631,
title = "Age-mediated changes in the gastrointestinal tract",
abstract = "Physiological functions of the two extreme ends of the age spectrum, children (<18 y old) and older adults (aged 65 y and over), differ from healthy young adults. This consequently affects the pharmacokinetic profiles of administered drugs, which, in turn, impacts upon clinical practice and drug therapy. The gastrointestinal milieu acts as a distinct and vital organ regulating the dissolution, absorption and metabolism of orally ingested drugs. Age-mediated alteration in the physiology and function of the gut can reshape the pharmacokinetics of certain drugs. However, our understanding of this topic is limited. This article references the gut physiology of healthy adults to capture the available evidence in the literature on the extent and nature of the changes in childhood and older age. The gut, as an organ, is examined with regards to the effect of age on luminal fluid, microbiota, transit and motility, and the intestinal mucosa. Whilst drastic developmental changes were observed in certain aspects of the gastrointestinal environment, the examination reveals significant gaps in our knowledge in the physiology and function of the developing or ageing gut. The revelation of the unknown paves the way towards a better characterization of the human gastrointestinal tract for optimized drug therapy in children and older adults.",
author = "Hamid Merchant and Fang Liu and {Orlu Gul}, Mine and Abdul Basit",
note = "This document is the accepted manuscript version for the following article, {"}Hamid A. Merchant, et al., “Age-mediated changes in the gastrointestinal tract”, International Journal of Pharmaceutics, Vol. 512(2): 382-395, April 2016.{"} The final published version is available at: https://doi.org/10.1016/j.ijpharm.2016.04.024 Copyright {\circledC} 2016, Elsevier.",
year = "2016",
month = "10",
day = "30",
doi = "10.1016/j.ijpharm.2016.04.024",
language = "English",
volume = "512",
pages = "382--395",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Age-mediated changes in the gastrointestinal tract

AU - Merchant, Hamid

AU - Liu, Fang

AU - Orlu Gul, Mine

AU - Basit, Abdul

N1 - This document is the accepted manuscript version for the following article, "Hamid A. Merchant, et al., “Age-mediated changes in the gastrointestinal tract”, International Journal of Pharmaceutics, Vol. 512(2): 382-395, April 2016." The final published version is available at: https://doi.org/10.1016/j.ijpharm.2016.04.024 Copyright © 2016, Elsevier.

PY - 2016/10/30

Y1 - 2016/10/30

N2 - Physiological functions of the two extreme ends of the age spectrum, children (<18 y old) and older adults (aged 65 y and over), differ from healthy young adults. This consequently affects the pharmacokinetic profiles of administered drugs, which, in turn, impacts upon clinical practice and drug therapy. The gastrointestinal milieu acts as a distinct and vital organ regulating the dissolution, absorption and metabolism of orally ingested drugs. Age-mediated alteration in the physiology and function of the gut can reshape the pharmacokinetics of certain drugs. However, our understanding of this topic is limited. This article references the gut physiology of healthy adults to capture the available evidence in the literature on the extent and nature of the changes in childhood and older age. The gut, as an organ, is examined with regards to the effect of age on luminal fluid, microbiota, transit and motility, and the intestinal mucosa. Whilst drastic developmental changes were observed in certain aspects of the gastrointestinal environment, the examination reveals significant gaps in our knowledge in the physiology and function of the developing or ageing gut. The revelation of the unknown paves the way towards a better characterization of the human gastrointestinal tract for optimized drug therapy in children and older adults.

AB - Physiological functions of the two extreme ends of the age spectrum, children (<18 y old) and older adults (aged 65 y and over), differ from healthy young adults. This consequently affects the pharmacokinetic profiles of administered drugs, which, in turn, impacts upon clinical practice and drug therapy. The gastrointestinal milieu acts as a distinct and vital organ regulating the dissolution, absorption and metabolism of orally ingested drugs. Age-mediated alteration in the physiology and function of the gut can reshape the pharmacokinetics of certain drugs. However, our understanding of this topic is limited. This article references the gut physiology of healthy adults to capture the available evidence in the literature on the extent and nature of the changes in childhood and older age. The gut, as an organ, is examined with regards to the effect of age on luminal fluid, microbiota, transit and motility, and the intestinal mucosa. Whilst drastic developmental changes were observed in certain aspects of the gastrointestinal environment, the examination reveals significant gaps in our knowledge in the physiology and function of the developing or ageing gut. The revelation of the unknown paves the way towards a better characterization of the human gastrointestinal tract for optimized drug therapy in children and older adults.

UR - https://www.ncbi.nlm.nih.gov/pubmed/27085646

U2 - 10.1016/j.ijpharm.2016.04.024

DO - 10.1016/j.ijpharm.2016.04.024

M3 - Article

VL - 512

SP - 382

EP - 395

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 2

ER -