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An investigation into the influence of binary drug solutions upon diffusion and partition processes in model membranes. / Fiala, Sarah; Brown, Marc; Jones, Stuart A.

In: Journal of Pharmacy and Pharmacology, Vol. 60, No. 12, 12.2008, p. 1615-1623.

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@article{29b95381cfc541dcb4e388330147338c,
title = "An investigation into the influence of binary drug solutions upon diffusion and partition processes in model membranes",
abstract = "Few studies have assessed the impact of binary systems on the fundamental mathematical models that describe drug permeation. The aim of this work was to determine the influence of varying the proportions of prilocaine and lidocaine in a binary saturated solution on mass transfer across synthetic membranes. Infinite-dose permeation studies were performed using Franz diffusion cells with either regenerated cellulose or silicone membranes, and partition coefficients were determined by drug loss over 24 h. There was a linear relationship between the flux of prilocaine and lidocaine through regenerated cellulose membrane (R2 ≥ 0.985, n = 5) and their normalised ratio in solution. This linear model was also applicable for the permeation of prilocaine through silicone membrane (R2 = 0.991, n = 5), as its partition coefficient was independent of the drug ratio (15.84 ± 1.41). However, the partition coefficient of lidocaine increased from 27.22 ± 1.68 to 47.03 ± 3.32 as the ratio of prilocaine increased and this resulted in a non-linear relationship between permeation and drug ratio. Irrespective of the membrane used, the permeation of one drug from a binary system was hindered by the presence of the second, which could be attributed to a reduction in available membrane diffusion volume.",
keywords = "H-BONDING GROUPS, IN-VITRO, SUPERSATURATED SOLUTIONS, CELLOPHANE MEMBRANES, ARTIFICIAL MEMBRANES, ENHANCED PERMEATION, DERMAL DELIVERY, HUMAN SKIN, RELEASE, PERMEABILITY",
author = "Sarah Fiala and Marc Brown and Jones, {Stuart A.}",
note = "Original article can be found at: http://www.medicinescomplete.com/journals/jpp/current/ Copyright Pharmaceutical Press. DOI: 10.1211/jpp/60.12.0007 [Full text of this article is not available in the UHRA]",
year = "2008",
month = "12",
doi = "10.1211/jpp/60.12.0007",
language = "English",
volume = "60",
pages = "1615--1623",
journal = "Journal of Pharmacy and Pharmacology",
issn = "0022-3573",
publisher = "Pharmaceutical Press",
number = "12",

}

RIS

TY - JOUR

T1 - An investigation into the influence of binary drug solutions upon diffusion and partition processes in model membranes

AU - Fiala, Sarah

AU - Brown, Marc

AU - Jones, Stuart A.

N1 - Original article can be found at: http://www.medicinescomplete.com/journals/jpp/current/ Copyright Pharmaceutical Press. DOI: 10.1211/jpp/60.12.0007 [Full text of this article is not available in the UHRA]

PY - 2008/12

Y1 - 2008/12

N2 - Few studies have assessed the impact of binary systems on the fundamental mathematical models that describe drug permeation. The aim of this work was to determine the influence of varying the proportions of prilocaine and lidocaine in a binary saturated solution on mass transfer across synthetic membranes. Infinite-dose permeation studies were performed using Franz diffusion cells with either regenerated cellulose or silicone membranes, and partition coefficients were determined by drug loss over 24 h. There was a linear relationship between the flux of prilocaine and lidocaine through regenerated cellulose membrane (R2 ≥ 0.985, n = 5) and their normalised ratio in solution. This linear model was also applicable for the permeation of prilocaine through silicone membrane (R2 = 0.991, n = 5), as its partition coefficient was independent of the drug ratio (15.84 ± 1.41). However, the partition coefficient of lidocaine increased from 27.22 ± 1.68 to 47.03 ± 3.32 as the ratio of prilocaine increased and this resulted in a non-linear relationship between permeation and drug ratio. Irrespective of the membrane used, the permeation of one drug from a binary system was hindered by the presence of the second, which could be attributed to a reduction in available membrane diffusion volume.

AB - Few studies have assessed the impact of binary systems on the fundamental mathematical models that describe drug permeation. The aim of this work was to determine the influence of varying the proportions of prilocaine and lidocaine in a binary saturated solution on mass transfer across synthetic membranes. Infinite-dose permeation studies were performed using Franz diffusion cells with either regenerated cellulose or silicone membranes, and partition coefficients were determined by drug loss over 24 h. There was a linear relationship between the flux of prilocaine and lidocaine through regenerated cellulose membrane (R2 ≥ 0.985, n = 5) and their normalised ratio in solution. This linear model was also applicable for the permeation of prilocaine through silicone membrane (R2 = 0.991, n = 5), as its partition coefficient was independent of the drug ratio (15.84 ± 1.41). However, the partition coefficient of lidocaine increased from 27.22 ± 1.68 to 47.03 ± 3.32 as the ratio of prilocaine increased and this resulted in a non-linear relationship between permeation and drug ratio. Irrespective of the membrane used, the permeation of one drug from a binary system was hindered by the presence of the second, which could be attributed to a reduction in available membrane diffusion volume.

KW - H-BONDING GROUPS

KW - IN-VITRO

KW - SUPERSATURATED SOLUTIONS

KW - CELLOPHANE MEMBRANES

KW - ARTIFICIAL MEMBRANES

KW - ENHANCED PERMEATION

KW - DERMAL DELIVERY

KW - HUMAN SKIN

KW - RELEASE

KW - PERMEABILITY

U2 - 10.1211/jpp/60.12.0007

DO - 10.1211/jpp/60.12.0007

M3 - Article

VL - 60

SP - 1615

EP - 1623

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

SN - 0022-3573

IS - 12

ER -