University of Hertfordshire

Anosognosia for hemiplegia as a tripartite disconnection syndrome

Research output: Contribution to journalArticle

  • Valentina Pacella
  • Chris Foulon
  • Paul M Jenkinson
  • Michele Scandola
  • Sara Bertagnoli
  • Renato Avesani
  • Aikaterini Fotopoulou
  • Valentina Moro
  • Michel Thiebaut de Schotten
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Original languageEnglish
Article numbere46075
Journal publication date6 Aug 2019
Publication statusPublished - 6 Aug 2019
Externally publishedYes


The syndrome of Anosognosia for Hemiplegia (AHP) can provide unique insights into the neurocognitive processes of motor awareness. Yet, prior studies have only explored predominately discreet lesions. Using advanced structural neuroimaging methods in 174 patients with a right-hemisphere stroke, we were able to identify three neural systems that contribute to AHP, when disconnected or directly damaged: the (i) premotor loop (ii) limbic system, and (iii) ventral attentional network. Our results suggest that human motor awareness is contingent on the joint contribution of these three systems.


© 2019, Pacella et al.

ID: 17192229