University of Hertfordshire

From the same journal

By the same authors

Antisense effects of PNAs in bacteria

Research output: Contribution to journalArticle

View graph of relations
Original languageEnglish
Number of pages14
Pages (from-to)223-36
JournalMethods in Molecular Biology
Journal publication date2014
Volume1050
DOIs
Publication statusPublished - 2014

Abstract

Peptide nucleic acids (PNAs) are a class of artificial DNA/RNA analogues that have unique physicochemical properties, which include a high chemical stability, resistance to nucleases and proteases and higher mismatch sensitivity than DNA. PNAs were initially anticipated to be useful for application in antisense and antigene therapies; however, their poor cellular uptake has limited their use for such purposes in the "real world". Recently, it has been shown that the addition of metal complexes to these oligonucleotide analogues could open up new avenues for their utilization in various research fields. Such metallo-constructs have shown great promise, for a diverse range of applications, most notably in the biosensing area. In this chapter, we report on the recent synthetic advances towards the preparation of these "(multi)-metallic PNAs" on the solid phase.

ID: 11775453