University of Hertfordshire

Standard

Bright conjugated polymer nanoparticles containing a biodegradable shell produced at high yields and with tuneable optical properties by a scalable microfluidic device. / Abelha, T. F.; Phillips, T. W.; Bannock, J. H.; Nightingale, A. M.; Dreiss, C. A.; Kemal, E.; Urbano, L.; Demello, J. C.; Green, M.; Dailey, L. A.

In: Nanoscale, Vol. 9, No. 5, 07.02.2017, p. 2009-2019.

Research output: Contribution to journalArticle

Harvard

Abelha, TF, Phillips, TW, Bannock, JH, Nightingale, AM, Dreiss, CA, Kemal, E, Urbano, L, Demello, JC, Green, M & Dailey, LA 2017, 'Bright conjugated polymer nanoparticles containing a biodegradable shell produced at high yields and with tuneable optical properties by a scalable microfluidic device', Nanoscale, vol. 9, no. 5, pp. 2009-2019. https://doi.org/10.1039/c6nr09162h

APA

Abelha, T. F., Phillips, T. W., Bannock, J. H., Nightingale, A. M., Dreiss, C. A., Kemal, E., ... Dailey, L. A. (2017). Bright conjugated polymer nanoparticles containing a biodegradable shell produced at high yields and with tuneable optical properties by a scalable microfluidic device. Nanoscale, 9(5), 2009-2019. https://doi.org/10.1039/c6nr09162h

Vancouver

Author

Abelha, T. F. ; Phillips, T. W. ; Bannock, J. H. ; Nightingale, A. M. ; Dreiss, C. A. ; Kemal, E. ; Urbano, L. ; Demello, J. C. ; Green, M. ; Dailey, L. A. / Bright conjugated polymer nanoparticles containing a biodegradable shell produced at high yields and with tuneable optical properties by a scalable microfluidic device. In: Nanoscale. 2017 ; Vol. 9, No. 5. pp. 2009-2019.

Bibtex

@article{6213491c785b4c04ac8c5dc187989568,
title = "Bright conjugated polymer nanoparticles containing a biodegradable shell produced at high yields and with tuneable optical properties by a scalable microfluidic device",
abstract = "This study compares the performance of a microfluidic technique and a conventional bulk method to manufacture conjugated polymer nanoparticles (CPNs) embedded within a biodegradable poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) (PEG5K-PLGA55K) matrix. The influence of PEG5K-PLGA55K and conjugated polymers cyano-substituted poly(p-phenylene vinylene) (CN-PPV) and poly(9,9-dioctylfluorene-2,1,3-benzothiadiazole) (F8BT) on the physicochemical properties of the CPNs was also evaluated. Both techniques enabled CPN production with high end product yields (∼70-95{\%}). However, while the bulk technique (solvent displacement) under optimal conditions generated small nanoparticles (∼70-100 nm) with similar optical properties (quantum yields ∼35{\%}), the microfluidic approach produced larger CPNs (140-260 nm) with significantly superior quantum yields (49-55{\%}) and tailored emission spectra. CPNs containing CN-PPV showed smaller size distributions and tuneable emission spectra compared to F8BT systems prepared under the same conditions. The presence of PEG5K-PLGA55K did not affect the size or optical properties of the CPNs and provided a neutral net electric charge as is often required for biomedical applications. The microfluidics flow-based device was successfully used for the continuous preparation of CPNs over a 24 hour period. On the basis of the results presented here, it can be concluded that the microfluidic device used in this study can be used to optimize the production of bright CPNs with tailored properties with good reproducibility.",
author = "Abelha, {T. F.} and Phillips, {T. W.} and Bannock, {J. H.} and Nightingale, {A. M.} and Dreiss, {C. A.} and E. Kemal and L. Urbano and Demello, {J. C.} and M. Green and Dailey, {L. A.}",
year = "2017",
month = "2",
day = "7",
doi = "10.1039/c6nr09162h",
language = "English",
volume = "9",
pages = "2009--2019",
journal = "Nanoscale",
issn = "2040-3364",
publisher = "Royal Society of Chemistry",
number = "5",

}

RIS

TY - JOUR

T1 - Bright conjugated polymer nanoparticles containing a biodegradable shell produced at high yields and with tuneable optical properties by a scalable microfluidic device

AU - Abelha, T. F.

AU - Phillips, T. W.

AU - Bannock, J. H.

AU - Nightingale, A. M.

AU - Dreiss, C. A.

AU - Kemal, E.

AU - Urbano, L.

AU - Demello, J. C.

AU - Green, M.

AU - Dailey, L. A.

PY - 2017/2/7

Y1 - 2017/2/7

N2 - This study compares the performance of a microfluidic technique and a conventional bulk method to manufacture conjugated polymer nanoparticles (CPNs) embedded within a biodegradable poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) (PEG5K-PLGA55K) matrix. The influence of PEG5K-PLGA55K and conjugated polymers cyano-substituted poly(p-phenylene vinylene) (CN-PPV) and poly(9,9-dioctylfluorene-2,1,3-benzothiadiazole) (F8BT) on the physicochemical properties of the CPNs was also evaluated. Both techniques enabled CPN production with high end product yields (∼70-95%). However, while the bulk technique (solvent displacement) under optimal conditions generated small nanoparticles (∼70-100 nm) with similar optical properties (quantum yields ∼35%), the microfluidic approach produced larger CPNs (140-260 nm) with significantly superior quantum yields (49-55%) and tailored emission spectra. CPNs containing CN-PPV showed smaller size distributions and tuneable emission spectra compared to F8BT systems prepared under the same conditions. The presence of PEG5K-PLGA55K did not affect the size or optical properties of the CPNs and provided a neutral net electric charge as is often required for biomedical applications. The microfluidics flow-based device was successfully used for the continuous preparation of CPNs over a 24 hour period. On the basis of the results presented here, it can be concluded that the microfluidic device used in this study can be used to optimize the production of bright CPNs with tailored properties with good reproducibility.

AB - This study compares the performance of a microfluidic technique and a conventional bulk method to manufacture conjugated polymer nanoparticles (CPNs) embedded within a biodegradable poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) (PEG5K-PLGA55K) matrix. The influence of PEG5K-PLGA55K and conjugated polymers cyano-substituted poly(p-phenylene vinylene) (CN-PPV) and poly(9,9-dioctylfluorene-2,1,3-benzothiadiazole) (F8BT) on the physicochemical properties of the CPNs was also evaluated. Both techniques enabled CPN production with high end product yields (∼70-95%). However, while the bulk technique (solvent displacement) under optimal conditions generated small nanoparticles (∼70-100 nm) with similar optical properties (quantum yields ∼35%), the microfluidic approach produced larger CPNs (140-260 nm) with significantly superior quantum yields (49-55%) and tailored emission spectra. CPNs containing CN-PPV showed smaller size distributions and tuneable emission spectra compared to F8BT systems prepared under the same conditions. The presence of PEG5K-PLGA55K did not affect the size or optical properties of the CPNs and provided a neutral net electric charge as is often required for biomedical applications. The microfluidics flow-based device was successfully used for the continuous preparation of CPNs over a 24 hour period. On the basis of the results presented here, it can be concluded that the microfluidic device used in this study can be used to optimize the production of bright CPNs with tailored properties with good reproducibility.

UR - http://www.scopus.com/inward/record.url?scp=85011422765&partnerID=8YFLogxK

U2 - 10.1039/c6nr09162h

DO - 10.1039/c6nr09162h

M3 - Article

VL - 9

SP - 2009

EP - 2019

JO - Nanoscale

JF - Nanoscale

SN - 2040-3364

IS - 5

ER -