University of Hertfordshire

Cerebellar output controls generalized spike-and-wave discharge occurence

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  • Lieke Kros
  • Oscar Eelkman Rooda
  • Jochen Spanke
  • Parimala Alva
  • Marijn van Dongen
  • Athanasios Karapatis
  • Else Tolner
  • Christos Strydis
  • N. Davey
  • Beerend Winkelman
  • Mario Negrello
  • Wouter Serdijn
  • Volker Steuber
  • Arn van den Maagdenberg
  • Chris I. De Zeeuw
  • Freek E. Hoebeek
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Original languageEnglish
Pages (from-to)1027-1049
JournalAnnals of Neurology
Journal publication dateJun 2015
Volume77
Issue6
Early online date11 Mar 2015
DOIs
StatePublished - Jun 2015

Abstract

Disrupting thalamocortical activity patterns has proven to be a promising approach to stop generalized spike-and-wave discharges (GSWDs) characteristic of absence seizures. Here, we investigated to what extent modulation of neuronal firing in cerebellar nuclei (CN), which are anatomically in an advantageous position to disrupt cortical oscillations through their innervation of a wide variety of thalamic nuclei, is effective in controlling absence seizures

Notes

Date of Acceptance: 03/03/2015. © 2015 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made

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