University of Hertfordshire

From the same journal

By the same authors

Cerebral lateralization is delayed in children who later develop schizophrenia

Research output: Contribution to journalArticle

View graph of relations
Original languageEnglish
Pages (from-to)181-185
JournalSchizophrenia Research
Journal publication date1996
Volume22
Issue3
DOIs
Publication statusPublished - 1996

Abstract

The origins of schizophrenia are obscure. One suggestion is that it represents a component of the genetic variation associated with the establishment of dominance in one or other cerebral hemisphere, a mechanism that has been crucial in the evolution of language. Indices of cerebral hemispheric dominance (hand, foot and eye preference, speed of checking squares) recorded on the I6 980 children in the UK National Child Development Study cohort were examined in relation to psychiatric admission by the age of 28 years. Diagnoses were established by the application of Present State Examination criteria to case notes. Pre-schizophrenic children (n = 34−36) were more likely (p < 0.0003) to be rated by their mothers as ambidextrous at the age of 7 years, and at 11 years were less (p < 0.01) strongly right-handed than their peers in the cohort population on a test of relative hand skill: children who later developed affective psychosis (n=25) or neurosis (n=60) did not differ significantly from controls. Delay in establishing dominance in one hemisphere could be the critical factor that predisposes to schizophrenia.

Notes

Original article can be found at: http://www.sciencedirect.com/science/journal/09209964 Copyright Elsevier. DOI: 10.1016/S0920-9964(96)00068-0 [Full text of this article is not available in the UHRA]

ID: 189957