University of Hertfordshire

From the same journal

By the same authors

  • Victoria Hutter
  • Constanze Hilgendorf
  • Alan Brown
  • Anne Cooper
  • Vanessa Zann
  • David Pritchard
  • Cynthia Bosquillon
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Original languageEnglish
Number of pages1
Pages (from-to)1225-1226
JournalJournal of Pharmacy and Pharmacology
Journal publication dateOct 2010
Volume62
Issue10
Publication statusPublished - Oct 2010
EventUK-PHARMSCI Conf - , United Kingdom
Duration: 1 Sep 20103 Sep 2010

Abstract

Expression and functionality of ATP-binding cassette (ABC) transporters were assessed in Calu-3 cell monolayers cultured at an air-liquid interface. Transporter gene expression was in agreement with published data in human lungs with the exception of BSEP which was over-expressed in Calu-3 cells. Net secretory transport of the ABC substrate 3H-digoxin was reduced in presence of the inhibitors verapamil, PSC833 and MK571. However, the transporter(s) involved could not be identified.

ID: 7983713