University of Hertfordshire

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Characteristics and outcome of patients with newly diagnosed advanced or metastatic lung cancer admitted to intensive care units (ICUs). / Barth, C; Soares, M; Toffart, A C; Timsit, J F; Burghi, G; Irrazabal, C; Pattison, N; Tobar, E; Almeida, B F; Silva, U V; Azevedo, L C; Rabbat, A; Lamer, C; Parrot, A; Souza-Dantas, V C; Wallet, F; Blot, F; Bourdin, G; Piras, C; Delemazure, J; Durand, M; Salluh, J; Azoulay, E; Lemiale, Virginie.

In: Annals of intensive care, Vol. 8, No. 1, 80, 04.08.2018.

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Barth, C, Soares, M, Toffart, AC, Timsit, JF, Burghi, G, Irrazabal, C, Pattison, N, Tobar, E, Almeida, BF, Silva, UV, Azevedo, LC, Rabbat, A, Lamer, C, Parrot, A, Souza-Dantas, VC, Wallet, F, Blot, F, Bourdin, G, Piras, C, Delemazure, J, Durand, M, Salluh, J, Azoulay, E & Lemiale, V 2018, 'Characteristics and outcome of patients with newly diagnosed advanced or metastatic lung cancer admitted to intensive care units (ICUs)', Annals of intensive care, vol. 8, no. 1, 80. https://doi.org/10.1186/s13613-018-0426-2

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Author

Barth, C ; Soares, M ; Toffart, A C ; Timsit, J F ; Burghi, G ; Irrazabal, C ; Pattison, N ; Tobar, E ; Almeida, B F ; Silva, U V ; Azevedo, L C ; Rabbat, A ; Lamer, C ; Parrot, A ; Souza-Dantas, V C ; Wallet, F ; Blot, F ; Bourdin, G ; Piras, C ; Delemazure, J ; Durand, M ; Salluh, J ; Azoulay, E ; Lemiale, Virginie. / Characteristics and outcome of patients with newly diagnosed advanced or metastatic lung cancer admitted to intensive care units (ICUs). In: Annals of intensive care. 2018 ; Vol. 8, No. 1.

Bibtex

@article{dd12067fc2fb4e74b97a731b77cb1f97,
title = "Characteristics and outcome of patients with newly diagnosed advanced or metastatic lung cancer admitted to intensive care units (ICUs)",
abstract = "BACKGROUND: Although patients with advanced or metastatic lung cancer have poor prognosis, admission to the ICU for management of life-threatening complications has increased over the years. Patients with newly diagnosed lung cancer appear as good candidates for ICU admission, but more robust information to assist decisions is lacking. The aim of our study was to evaluate the prognosis of newly diagnosed unresectable lung cancer patients.METHODS: A retrospective multicentric study analyzed the outcome of patients admitted to the ICU with a newly diagnosed lung cancer (diagnosis within the month) between 2010 and 2013.RESULTS: Out of the 100 patients, 30 had small cell lung cancer (SCLC) and 70 had non-small cell lung cancer. (Thirty patients had already been treated with oncologic treatments.) Mechanical ventilation (MV) was performed for 81 patients. Seventeen patients received emergency chemotherapy during their ICU stay. ICU, hospital, 3- and 6-month mortality were, respectively, 47, 60, 67 and 71{\%}. Hospital mortality was 60{\%} when invasive MV was used alone, 71{\%} when MV and vasopressors were needed and 83{\%} when MV, vasopressors and hemodialysis were required. In multivariate analysis, hospital mortality was associated with metastatic disease (OR 4.22 [1.4-12.4]; p = 0.008), need for invasive MV (OR 4.20 [1.11-16.2]; p = 0.030), while chemotherapy in ICU was associated with survival (OR 0.23, [0.07-0.81]; p = 0.020).CONCLUSION: This study shows that ICU management can be appropriate for selected newly diagnosed patients with advanced lung cancer, and chemotherapy might improve outcome for patients with SCLC admitted for cancer-related complications. Nevertheless, tumors' characteristics, numbers and types of organ dysfunction should be taken into account in the decisional process before admitting these patients in ICU.",
keywords = "Chemotherapy, Intensive care, Lung cancer, Metastatic, Outcome",
author = "C Barth and M Soares and Toffart, {A C} and Timsit, {J F} and G Burghi and C Irrazabal and N Pattison and E Tobar and Almeida, {B F} and Silva, {U V} and Azevedo, {L C} and A Rabbat and C Lamer and A Parrot and Souza-Dantas, {V C} and F Wallet and F Blot and G Bourdin and C Piras and J Delemazure and M Durand and J Salluh and E Azoulay and Virginie Lemiale",
year = "2018",
month = "8",
day = "4",
doi = "10.1186/s13613-018-0426-2",
language = "English",
volume = "8",
journal = "Annals of intensive care",
issn = "2110-5820",
publisher = "Springer-Verlag GmbH and Co. KG",
number = "1",

}

RIS

TY - JOUR

T1 - Characteristics and outcome of patients with newly diagnosed advanced or metastatic lung cancer admitted to intensive care units (ICUs)

AU - Barth, C

AU - Soares, M

AU - Toffart, A C

AU - Timsit, J F

AU - Burghi, G

AU - Irrazabal, C

AU - Pattison, N

AU - Tobar, E

AU - Almeida, B F

AU - Silva, U V

AU - Azevedo, L C

AU - Rabbat, A

AU - Lamer, C

AU - Parrot, A

AU - Souza-Dantas, V C

AU - Wallet, F

AU - Blot, F

AU - Bourdin, G

AU - Piras, C

AU - Delemazure, J

AU - Durand, M

AU - Salluh, J

AU - Azoulay, E

AU - Lemiale, Virginie

PY - 2018/8/4

Y1 - 2018/8/4

N2 - BACKGROUND: Although patients with advanced or metastatic lung cancer have poor prognosis, admission to the ICU for management of life-threatening complications has increased over the years. Patients with newly diagnosed lung cancer appear as good candidates for ICU admission, but more robust information to assist decisions is lacking. The aim of our study was to evaluate the prognosis of newly diagnosed unresectable lung cancer patients.METHODS: A retrospective multicentric study analyzed the outcome of patients admitted to the ICU with a newly diagnosed lung cancer (diagnosis within the month) between 2010 and 2013.RESULTS: Out of the 100 patients, 30 had small cell lung cancer (SCLC) and 70 had non-small cell lung cancer. (Thirty patients had already been treated with oncologic treatments.) Mechanical ventilation (MV) was performed for 81 patients. Seventeen patients received emergency chemotherapy during their ICU stay. ICU, hospital, 3- and 6-month mortality were, respectively, 47, 60, 67 and 71%. Hospital mortality was 60% when invasive MV was used alone, 71% when MV and vasopressors were needed and 83% when MV, vasopressors and hemodialysis were required. In multivariate analysis, hospital mortality was associated with metastatic disease (OR 4.22 [1.4-12.4]; p = 0.008), need for invasive MV (OR 4.20 [1.11-16.2]; p = 0.030), while chemotherapy in ICU was associated with survival (OR 0.23, [0.07-0.81]; p = 0.020).CONCLUSION: This study shows that ICU management can be appropriate for selected newly diagnosed patients with advanced lung cancer, and chemotherapy might improve outcome for patients with SCLC admitted for cancer-related complications. Nevertheless, tumors' characteristics, numbers and types of organ dysfunction should be taken into account in the decisional process before admitting these patients in ICU.

AB - BACKGROUND: Although patients with advanced or metastatic lung cancer have poor prognosis, admission to the ICU for management of life-threatening complications has increased over the years. Patients with newly diagnosed lung cancer appear as good candidates for ICU admission, but more robust information to assist decisions is lacking. The aim of our study was to evaluate the prognosis of newly diagnosed unresectable lung cancer patients.METHODS: A retrospective multicentric study analyzed the outcome of patients admitted to the ICU with a newly diagnosed lung cancer (diagnosis within the month) between 2010 and 2013.RESULTS: Out of the 100 patients, 30 had small cell lung cancer (SCLC) and 70 had non-small cell lung cancer. (Thirty patients had already been treated with oncologic treatments.) Mechanical ventilation (MV) was performed for 81 patients. Seventeen patients received emergency chemotherapy during their ICU stay. ICU, hospital, 3- and 6-month mortality were, respectively, 47, 60, 67 and 71%. Hospital mortality was 60% when invasive MV was used alone, 71% when MV and vasopressors were needed and 83% when MV, vasopressors and hemodialysis were required. In multivariate analysis, hospital mortality was associated with metastatic disease (OR 4.22 [1.4-12.4]; p = 0.008), need for invasive MV (OR 4.20 [1.11-16.2]; p = 0.030), while chemotherapy in ICU was associated with survival (OR 0.23, [0.07-0.81]; p = 0.020).CONCLUSION: This study shows that ICU management can be appropriate for selected newly diagnosed patients with advanced lung cancer, and chemotherapy might improve outcome for patients with SCLC admitted for cancer-related complications. Nevertheless, tumors' characteristics, numbers and types of organ dysfunction should be taken into account in the decisional process before admitting these patients in ICU.

KW - Chemotherapy

KW - Intensive care

KW - Lung cancer

KW - Metastatic

KW - Outcome

UR - http://www.scopus.com/inward/record.url?scp=85051208112&partnerID=8YFLogxK

U2 - 10.1186/s13613-018-0426-2

DO - 10.1186/s13613-018-0426-2

M3 - Article

C2 - 30076547

VL - 8

JO - Annals of intensive care

JF - Annals of intensive care

SN - 2110-5820

IS - 1

M1 - 80

ER -