University of Hertfordshire

Clinical cytogenetics in pediatric acute leukemia: an update

Research output: Contribution to journalReview article

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Original languageEnglish
Number of pages8
Pages (from-to)230-237
JournalClinical lymphoma, myeloma & leukemia
Journal publication date1 Aug 2012
Volume12
Issue4
Early online date19 May 2012
DOIs
Publication statusPublished - 1 Aug 2012

Abstract

Pediatric acute leukemias are generally characterized by recurrent numerical and structural chromosomal abnormalities, which are thought to be specifically associated with diagnosis and prognosis of both childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The identification of those chromosomal aberrations is clinically important because they are considered significant risk-stratifying markers. However there have been several instances in which they remain undetectable, possibly due to the low resolution of most genetic screening tools used. In the present review, the clinical significance of most chromosomal aberrations associated with pediatric ALL and AML as well as the current technology used for their identification is discussed.

Notes

© 2012. Published by Elsevier Inc. All rights reserved.

ID: 15938353