University of Hertfordshire

Documents

  • Guogang Ren
  • Mohan Edirisinghe
  • Esra Altun
  • Mehmet Onur Aydogdu
  • Maram Crabbe-Mann
  • Jubair Ahmed
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Original languageEnglish
Article number1800537
Number of pages14
JournalMacromolecular Materials and Engineering
Journal publication date1 Jan 2019
Volume304
Issue1
Early online date28 Nov 2018
DOIs
Publication statusPublished - 1 Jan 2019

Abstract

Pressurized gyration and its sister processes are novel methods to produce polymeric fibers. Potential applications for such fibers include wound dressings, tissue engineering scaffolds, and filters. This study reports on a pressurized gyration technique that employs pressured N2 gas to prepare biocompatible wound dressing bandages from bacterial cellulose and poly (methylmethacrylate) polymer blended with alloyed antimicrobial nanoparti-cles. Resulting bandages are manufactured with high product yield and char-acterized for their chemical, physical, and mechanical properties. Increased density in solutions with additional antimicrobial nanoparticles results in increased fiber diameters. Also, addition of antimicrobial nanoparticles enhances ultimate tensile strength and Young’s modulus of the bandages. Typical molecular bonding in the bandages is confirmed by Fourier-transform infrared spectroscopy, with peaks that have higher intensity and narrowing points being caused by additional antimicrobial nanoparticles. More so, the cellular response to the bandages and the accompanying antimicrobial activity are studied in detail by in vitro co-culture of Staphylococcus aureusand keratinocytes. Antimicrobial nanoparticle-loaded bandage samples show increased cell viability and bacteria inhibition during co-culture and are found to have a promising future as epidermal wound dressing materials.

Notes

© 2018 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

ID: 16241362