University of Hertfordshire

  • Kyriaki Hatziagapiou
  • Maria Braoudaki
  • Kostas Bethanis
  • Konstantina Yannakopoulou
  • Athanasios Anastasiou
  • Georgia Koutsouri
  • Dimitrios Koutsouris
  • George I. Lambrou
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Original languageEnglish
Title of host publication2018 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2018
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages194-197
Number of pages4
Volume2018-January
ISBN (Electronic)9781538624050
DOIs
Publication statusPublished - 9 Apr 2018
Event2018 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2018 - Las Vegas, United States
Duration: 4 Mar 20187 Mar 2018

Conference

Conference2018 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2018
CountryUnited States
CityLas Vegas
Period4/03/187/03/18

Abstract

Cyclodextrins (CD) have been playing a very important role in the formulation of poorly water-soluble drugs by improving apparent drug solubility and/or dissolution. In the current study we focused on the investigation of the cytotoxic effect of cyclodextrin/Gefitinib in inclusion with three types of cyclodextrin, as well as in its inhibitory activity of Epidermal Growth Factor Receptor (EGFR) tyrosine kinase activity using biological assays. The activity of Gefitinib and Gefitinib/cyclodextrin were measured in pediatric neuroblastoma (NB) tumor cell lines. We have shown that CD/Gefitinib complexes are effective against neuroblastoma cells in vitro. Our studies provided a detailed picture of inclusion of Gefitinib in cyclodextrins and verify improved efficacy of the CD-encapsulated drug in cytotoxicity assays on pediatric tumor cell lines. An understanding of the structural details of guest inclusion in CDs may be useful in the engineering of modified guest-host preparations with optimized pharmacological properties and shape future therapeutic strategies.

ID: 15938693