University of Hertfordshire

By the same authors

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Original languageEnglish
Publication statusPublished - 26 Nov 2015
EventAntibiotic Resistance Mechanisms Workshop (ARM 2015), Birmingham, UK -
Duration: 26 Nov 201527 Nov 2015

Conference

ConferenceAntibiotic Resistance Mechanisms Workshop (ARM 2015), Birmingham, UK
Abbreviated titleARM(2015)
Period26/11/1527/11/15

Abstract

A series of novel diketones were designed and
synthesised in an attempt to develop potent antimicrobial
agents. Their structures were confirmed by spectroscopic
techniques i.e. 1H and 13C-NMR, IR and LC-MS. The
minimum inhibitory concentration (MIC) was determined
against a wide range of bacteria using two fold micro
broth dilution method. Among the test Compounds DK2,
DK6, DK7, DK11, DK12, DK16 and DK17 were found to
have excellent activity against all Gram positive bacteria
with MIC values ranging 16-0.1μg/ml. The in vitro
cytotoxity of all the active compounds was assessed by
MTT clorimetric assay. The bioactive compounds
exhibited IC50 values against Caco-2 cells rainging 64-8ug/ml

Notes

Rajesh Garikipati, Olufunmilayo Mohammed, Sharon Rossiter, Simon Baines, Jatinder Bassin, Madhu Goyal, ‘Design, Synthesis and Antimicrobial Evaluation of the in vitro Efficacy of Novel Diketones’, poster presented at the Antibiotic Resistance Mechanisms Workshop (ARM 2015), Birmingham, UK, 26-27 November, 2015.

ID: 10264647