University of Hertfordshire

  • J.P. Mackay
  • U. Gerhard
  • D.A. Beauregard
  • R.A. Maplestone
  • D.H. Williams
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Original languageEnglish
Pages (from-to)4573-4580
Number of pages8
JournalJournal of the American Chemical Society
Publication statusPublished - 1 Jun 1994


A procedure for the determination of association constants in aqueous solution using hydrogen-deuterium exchange has been developed and used to measure the dimerization constant, K(dim), for a number of strongly dimerizing glycopeptide antibiotics. These values provide further insight into the thermodynamic contributions of various structural epitopes to the dimerization of these antibiotics. Consideration of ligand binding affinities together with dimerization potentials provides evidence that dimerization is implicated in the physiological mode of action of these antibiotics.

ID: 940383