University of Hertfordshire

  • W. J. He
  • Marc Brown
  • Gary P. Martin
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Original languageEnglish
Number of pages1
Pages (from-to)13
JournalJournal of Pharmacy and Pharmacology
Journal publication dateSep 2004
Volume56
IssueS1
DOIs
Publication statusPublished - Sep 2004

Abstract

Hyaluronan (HA) is a naturally occurring polyanionic glycosaminoglycan.
Drugs formulated in HA and applied topically are retained in the skin with
little systemic absorption (Brown et al 2000, 2001). However, the precise
mechanism of action of HA that facilitates drug delivery and promotes drug
localization remain unclear. In this study we investigated the in-vitro release
characteristics of two NSAID drugs, ibuprofen (IBF) and diclofenac sodium
(DFS), incorporated into vehicles containing four different molecular weight
(MW) grades and different concentrations of HA across cellulose membrane

Notes

BPC Science Abstracts

ID: 628296