University of Hertfordshire

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Endotoxemia in end-stage kidney disease

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Original languageEnglish
Number of pages9
Pages (from-to)59-67
JournalSeminars in Dialysis
Journal publication date8 Jan 2015
Volume28
Issue1
Early online date13 Jul 2014
DOIs
Publication statusPublished - 8 Jan 2015

Abstract

Chronic unexplained inflammation remains a prevalent and clinically significant problem for patients with end-stage kidney disease (ESKD), especially in the dialysis population. The causes of persistent inflammation are likely to be multifactorial, but the underlying mechanisms remain to be elucidated. Endotoxins are reported to play a significant role in the pathogenesis of inflammation in patients with ESKD. However, blood endotoxin measurement with the Limulus amoebocyte lysate (LAL) assay is difficult with current detection systems. The reported degree and prevalence of endotoxemia varies in the literature. There are questions as to whether endotoxemia is truly present; whether the varied findings are due to methodological issues with the LAL assay and whether any endotoxemia that might be present plays a role in chronic inflammation frequently observed in ESKD patients. This review will discuss the challenges of accurate blood endotoxin detection, the potential source of blood endotoxins, and the significance of endotoxemia to patient with ESKD.

Notes

Jonathan Wong, Enric Vilar, and Ken Farrington, 'Endotoxemia in End-Stage Kidney Disease', Seminars in Dialysis, Vol. 28 (1): 59-67, Jan-Feb 2015. Available online at doi: 10.1111/sdi.12280. © 2014 Wiley Periodicals, Inc.

ID: 10604427