University of Hertfordshire


  • Luisa Christensen
  • Rob Turner
  • Sean Weaver
  • Francesco Caserta
  • Lisa Long
  • Mahmoud Ghannoum
  • Marc Brown
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Original languageEnglish
Article numbere02554-16
JournalAntimicrobial Agents and Chemotherapy
Journal publication date1 Jul 2017
Publication statusPublished - 1 Jul 2017


In an effort to increase the efficacy of topical medications for treating onychomycosis, several new nail penetration enhancers were recently developed. In this study, the ability of 10% (wt/wt) miconazole nitrate combined with a penetration enhancer formulation to permeate the nail is demonstrated by the use of a selection of in vitro nail penetration assays. These assays included the bovine hoof, TurChub zone of inhibition, and infected-nail models.


This document is the Accepted Manuscript of the following article: Luisa Christensen, Rob Turner, Sean Weaver, Francesco Caserta, Lisa Long, Mahmoud Ghannoum, and Marc Brown, ‘Evaluation of the Ability of a Novel Miconazole Formulation To Penetrate Nail by Using Three In Vitro Nail Models’, Antimicrobial Agents and Chemotherapy, Vol. 61 (7): e02554-16, July 2017. The final, published version is available online at DOI:

ID: 13308673