University of Hertfordshire

Documents

  • Luisa Christensen
  • Rob Turner
  • Sean Weaver
  • Francesco Caserta
  • Lisa Long
  • Mahmoud Ghannoum
  • Marc Brown
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Original languageEnglish
Article numbere02554-16
JournalAntimicrobial Agents and Chemotherapy
Journal publication date1 Jul 2017
Volume61
Issue7
DOIs
Publication statusPublished - 1 Jul 2017

Abstract

In an effort to increase the efficacy of topical medications for treating onychomycosis, several new nail penetration enhancers were recently developed. In this study, the ability of 10% (wt/wt) miconazole nitrate combined with a penetration enhancer formulation to permeate the nail is demonstrated by the use of a selection of in vitro nail penetration assays. These assays included the bovine hoof, TurChub zone of inhibition, and infected-nail models.

Notes

This document is the Accepted Manuscript of the following article: Luisa Christensen, Rob Turner, Sean Weaver, Francesco Caserta, Lisa Long, Mahmoud Ghannoum, and Marc Brown, ‘Evaluation of the Ability of a Novel Miconazole Formulation To Penetrate Nail by Using Three In Vitro Nail Models’, Antimicrobial Agents and Chemotherapy, Vol. 61 (7): e02554-16, July 2017. The final, published version is available online at DOI: https://doi.org/10.1128/AAC.02554-16.

ID: 13308673