University of Hertfordshire

Documents

  • Sara Jaffari
  • Ben Forbes
  • Elizabeth Collins
  • Jiyi Khoo
  • Gary P. Martin
  • Darragh Murnane
View graph of relations
Original languageEnglish
Pages (from-to)3251-3264
JournalPharmaceutical Research
Journal publication date31 Dec 2014
Volume31
Issue12
Early online date12 Jul 2014
DOIs
Publication statusPublished - 31 Dec 2014

Abstract

Purpose: To investigate the agglomeration behaviour of the fine (< 5.0 µm) and coarse (> 12.8 µm) particle fractions of salmeterol xinafoate (SX) and fluticasone propionate (FP) by isolating aerodynamic size fractions and characterising their physicochemical and re-dispersal properties.
Methods: Aerodynamic fractionation was conducted using the Next Generation Impactor (NGI). Re-crystallized control particles, unfractionated and fractionated materials were characterized for particle size, morphology, crystallinity and surface energy. Re-dispersal of the particles was assessed using dry dispersion laser diffraction and NGI analysis.
Results: Aerosolized SX and FP particles deposited in the NGI as agglomerates of consistent particle/agglomerate morphology. SX particles depositing on Stages 3 and 5 had higher total surface energy than unfractionated SX, with Stage 5 particles showing the greatest surface energy heterogeneity. FP fractions had comparable surface energy distributions and bulk crystallinity but differences in surface chemistry. SX fractions demonstrated higher bulk disorder than unfractionated and re-crystallized particles. Upon aerosolization, the fractions differed in their intrinsic emission and dispersion into a fine particle fraction (< 5.0 µm).
Conclusions: Micronized powders consisted of sub-populations of particles displaying distinct physicochemical and powder dispersal properties compared to the unfractionated bulk material. This may have implications for the efficiency of inhaled drug delivery

Notes

This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

ID: 7186394