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Greater cognitive deterioration in women than men with Alzheimer's disease : a meta analysis. / Irvine, K.; Laws, K.R.; Gale, T.M.; Kondel, T.K.

In: Journal of Clinical and Experimental Neuropsychology, Vol. 34, No. 9, 01.11.2012, p. 989-998.

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@article{659192a282d740589a299dfab37019e4,
title = "Greater cognitive deterioration in women than men with Alzheimer's disease: a meta analysis",
abstract = "Studies reporting on the cognitive abilities of men and women with Alzheimer's disease (AD) are surprisingly rare. We carried out a meta-analysis of neurocognitive data from 15 studies (n = 828 men; 1,238 women), which revealed a consistent male advantage on verbal and visuospatial tasks and tests of episodic and semantic memory. Moderator regression analyses showed that age, education level, and dementia severity did not significantly predict the male advantage. Reasons posited for this advantage include a reduction of estrogen in postmenopausal women, sex differences in AD pathology, and greater cognitive reserve in men.",
keywords = "APOLIPOPROTEIN-E, OLDER-ADULTS, AGE, GENDER-DIFFERENCES, Alzheimer's disease, VASCULAR DEMENTIA, VERBAL MEMORY, SEX-DIFFERENCES, SURGICALLY MENOPAUSAL WOMEN, Sex differences, Cognition, Visuospatial abilities, ESTROGEN REPLACEMENT, Verbal abilities, REPLACEMENT THERAPY",
author = "K. Irvine and K.R. Laws and T.M. Gale and T.K. Kondel",
year = "2012",
month = "11",
day = "1",
doi = "10.1080/13803395.2012.712676",
language = "English",
volume = "34",
pages = "989--998",
journal = "Journal of Clinical and Experimental Neuropsychology",
issn = "1380-3395",
publisher = "Psychology Press Ltd",
number = "9",

}

RIS

TY - JOUR

T1 - Greater cognitive deterioration in women than men with Alzheimer's disease

T2 - a meta analysis

AU - Irvine, K.

AU - Laws, K.R.

AU - Gale, T.M.

AU - Kondel, T.K.

PY - 2012/11/1

Y1 - 2012/11/1

N2 - Studies reporting on the cognitive abilities of men and women with Alzheimer's disease (AD) are surprisingly rare. We carried out a meta-analysis of neurocognitive data from 15 studies (n = 828 men; 1,238 women), which revealed a consistent male advantage on verbal and visuospatial tasks and tests of episodic and semantic memory. Moderator regression analyses showed that age, education level, and dementia severity did not significantly predict the male advantage. Reasons posited for this advantage include a reduction of estrogen in postmenopausal women, sex differences in AD pathology, and greater cognitive reserve in men.

AB - Studies reporting on the cognitive abilities of men and women with Alzheimer's disease (AD) are surprisingly rare. We carried out a meta-analysis of neurocognitive data from 15 studies (n = 828 men; 1,238 women), which revealed a consistent male advantage on verbal and visuospatial tasks and tests of episodic and semantic memory. Moderator regression analyses showed that age, education level, and dementia severity did not significantly predict the male advantage. Reasons posited for this advantage include a reduction of estrogen in postmenopausal women, sex differences in AD pathology, and greater cognitive reserve in men.

KW - APOLIPOPROTEIN-E

KW - OLDER-ADULTS

KW - AGE

KW - GENDER-DIFFERENCES

KW - Alzheimer's disease

KW - VASCULAR DEMENTIA

KW - VERBAL MEMORY

KW - SEX-DIFFERENCES

KW - SURGICALLY MENOPAUSAL WOMEN

KW - Sex differences

KW - Cognition

KW - Visuospatial abilities

KW - ESTROGEN REPLACEMENT

KW - Verbal abilities

KW - REPLACEMENT THERAPY

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84868666775&partnerID=8YFLogxK

U2 - 10.1080/13803395.2012.712676

DO - 10.1080/13803395.2012.712676

M3 - Article

VL - 34

SP - 989

EP - 998

JO - Journal of Clinical and Experimental Neuropsychology

JF - Journal of Clinical and Experimental Neuropsychology

SN - 1380-3395

IS - 9

ER -