University of Hertfordshire

From the same journal

By the same authors

  • Samuel Antwi-Baffour
  • Sharad Kholia
  • Yushau K-D Aryee
  • Ephraim A Ansa-Addo
  • Dan Stratton
  • Sigrun Lange
  • Jameel M Inal
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Original languageEnglish
Number of pages6
Pages (from-to)278-83
JournalBiochemical and Biophysical Research Communications
Journal publication date23 Jul 2010
Volume398
Issue2
DOIs
Publication statusPublished - 23 Jul 2010

Abstract

Plasma membrane-derived vesicles (PMVs) also known as microparticles, are small membrane-bound vesicles released from the cell membrane via blebbing and shedding. PMVs have been linked with various physiological functions as well as pathological conditions such as inflammation, autoimmune disease and cardiovascular disease. PMVs are characterised by the expression of phosphatidylserine (PS) on the plasma membrane. PS, also expressed on apoptotic cells (ACs) enables macrophages to phagocytose ACs. As it is widely known that PMV production is increased during apoptosis, we were able to show that PMVs could compete dose dependently with ACs for the PS receptor on macrophages, so reducing phagocytosis of ACs. In a clinical setting this may result in secondary necrosis and further pathological conditions. In SLE in which there are raised PMV levels, there is an anti-phospholipid-mediated increase in PMV release, which can be abrogated by depletion of IgG. Our work provides an insight into how PMVs may play a role in the aetiology of autoimmune disease, in particular SLE.

ID: 13069501