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Imaging of X-Ray-Excited Emissions from Quantum Dots and Biological Tissue in Whole Mouse. / Ryan, Sean G.; Butler, Matthew N.; Adeyemi, Segun; Kalber, Tammy; Patrick, Peter Stephen; Thin, May Zaw; Harrison, Ian F.; Stuckey, Daniel J.; Pule, Martin; Lythgoe, Mark.

In: Scientific Reports, 29.11.2019.

Research output: Contribution to journalArticle

Harvard

Ryan, SG, Butler, MN, Adeyemi, S, Kalber, T, Patrick, PS, Thin, MZ, Harrison, IF, Stuckey, DJ, Pule, M & Lythgoe, M 2019, 'Imaging of X-Ray-Excited Emissions from Quantum Dots and Biological Tissue in Whole Mouse', Scientific Reports.

APA

Ryan, S. G., Butler, M. N., Adeyemi, S., Kalber, T., Patrick, P. S., Thin, M. Z., ... Lythgoe, M. (Accepted/In press). Imaging of X-Ray-Excited Emissions from Quantum Dots and Biological Tissue in Whole Mouse. Scientific Reports.

Vancouver

Ryan SG, Butler MN, Adeyemi S, Kalber T, Patrick PS, Thin MZ et al. Imaging of X-Ray-Excited Emissions from Quantum Dots and Biological Tissue in Whole Mouse. Scientific Reports. 2019 Nov 29.

Author

Ryan, Sean G. ; Butler, Matthew N. ; Adeyemi, Segun ; Kalber, Tammy ; Patrick, Peter Stephen ; Thin, May Zaw ; Harrison, Ian F. ; Stuckey, Daniel J. ; Pule, Martin ; Lythgoe, Mark. / Imaging of X-Ray-Excited Emissions from Quantum Dots and Biological Tissue in Whole Mouse. In: Scientific Reports. 2019.

Bibtex

@article{3e6f2b3a07b847cebe3cbb63538253c9,
title = "Imaging of X-Ray-Excited Emissions from Quantum Dots and Biological Tissue in Whole Mouse",
abstract = "Optical imaging in clinical and preclinical settings can provide a wealth of biological information, particularly when coupled with targetted nanoparticles, but optical scattering and absorption limit the depth and resolution in both animal and human subjects. Two new hybrid approaches are presented, using the penetrating power of X-rays to increase the depth of optical imaging. Foremost, we demonstrate the excitation by X-rays of quantum-dots (QD) emitting in the near-infrared (NIR), using a clinical X-ray system to map the distribution of QDs at depth in whole mouse. We elicit a clear, spatially-resolved NIR signal from deep organs (brain, liver and kidney) with short (1 second) exposures and tolerable radiation doses that will permit future in vivo applications. Furthermore, X-ray-excited endogenous emission is also detected from whole mouse. The use of keV X-rays to excite emission from QDs and tissue represent novel biomedical imaging technologies, and exploit emerging QDs as optical probes for spatial-temporal molecular imaging at greater depth than previously possible.",
keywords = "X-ray imaging, quantum dots, nanoparticles, biosensors, nanobiotechnology, optical imaging",
author = "Ryan, {Sean G.} and Butler, {Matthew N.} and Segun Adeyemi and Tammy Kalber and Patrick, {Peter Stephen} and Thin, {May Zaw} and Harrison, {Ian F.} and Stuckey, {Daniel J.} and Martin Pule and Mark Lythgoe",
year = "2019",
month = "11",
day = "29",
language = "English",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Imaging of X-Ray-Excited Emissions from Quantum Dots and Biological Tissue in Whole Mouse

AU - Ryan, Sean G.

AU - Butler, Matthew N.

AU - Adeyemi, Segun

AU - Kalber, Tammy

AU - Patrick, Peter Stephen

AU - Thin, May Zaw

AU - Harrison, Ian F.

AU - Stuckey, Daniel J.

AU - Pule, Martin

AU - Lythgoe, Mark

PY - 2019/11/29

Y1 - 2019/11/29

N2 - Optical imaging in clinical and preclinical settings can provide a wealth of biological information, particularly when coupled with targetted nanoparticles, but optical scattering and absorption limit the depth and resolution in both animal and human subjects. Two new hybrid approaches are presented, using the penetrating power of X-rays to increase the depth of optical imaging. Foremost, we demonstrate the excitation by X-rays of quantum-dots (QD) emitting in the near-infrared (NIR), using a clinical X-ray system to map the distribution of QDs at depth in whole mouse. We elicit a clear, spatially-resolved NIR signal from deep organs (brain, liver and kidney) with short (1 second) exposures and tolerable radiation doses that will permit future in vivo applications. Furthermore, X-ray-excited endogenous emission is also detected from whole mouse. The use of keV X-rays to excite emission from QDs and tissue represent novel biomedical imaging technologies, and exploit emerging QDs as optical probes for spatial-temporal molecular imaging at greater depth than previously possible.

AB - Optical imaging in clinical and preclinical settings can provide a wealth of biological information, particularly when coupled with targetted nanoparticles, but optical scattering and absorption limit the depth and resolution in both animal and human subjects. Two new hybrid approaches are presented, using the penetrating power of X-rays to increase the depth of optical imaging. Foremost, we demonstrate the excitation by X-rays of quantum-dots (QD) emitting in the near-infrared (NIR), using a clinical X-ray system to map the distribution of QDs at depth in whole mouse. We elicit a clear, spatially-resolved NIR signal from deep organs (brain, liver and kidney) with short (1 second) exposures and tolerable radiation doses that will permit future in vivo applications. Furthermore, X-ray-excited endogenous emission is also detected from whole mouse. The use of keV X-rays to excite emission from QDs and tissue represent novel biomedical imaging technologies, and exploit emerging QDs as optical probes for spatial-temporal molecular imaging at greater depth than previously possible.

KW - X-ray imaging

KW - quantum dots

KW - nanoparticles

KW - biosensors

KW - nanobiotechnology

KW - optical imaging

M3 - Article

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

ER -