University of Hertfordshire

Importance of endogenous fibrinolysis in platelet thrombus formation

Research output: Contribution to journalReview article


  • Ying X. Gue
  • Diana A. Gorog
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Original languageEnglish
Article number1850
JournalInternational Journal of Molecular Sciences
Journal publication date1 Sep 2017
Early online date25 Aug 2017
StatePublished - 1 Sep 2017


The processes of thrombosis and coagulation are finely regulated by endogenous fibrinolysis maintaining healthy equilibrium. When the balance is altered in favour of platelet activation and/or coagulation, or if endogenous fibrinolysis becomes less efficient, pathological thrombosis can occur. Arterial thrombosis remains a major cause of morbidity and mortality in the world despite advances in medical therapies. The role endogenous fibrinolysis in the pathogenesis of arterial thrombosis has gained increasing attention in recent years as it presents novel ways to prevent and treat existing diseases. In this review article, we discuss the role of endogenous fibrinolysis in platelet thrombus formation, methods of measurement of fibrinolytic activity, its role in predicting cardiovascular diseases and clinical outcomes and future directions.

ID: 12446210