University of Hertfordshire

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Documents

  • Laura Urbano
  • Luke Clifton
  • Hoi Ki Ku
  • Hannah Kendall-Troughton
  • Kalliopi Kelli A. Vandera
  • Bruno F.E. Matarese
  • Thais Abelha
  • Peixun Li
  • Tejal Desai
  • Cécile A. Dreiss
  • Robert D. Barker
  • Mark A. Green
  • Lea Ann Dailey
  • Richard D. Harvey
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Original languageEnglish
Number of pages13
Pages (from-to)6125-6137
JournalLangmuir
Journal publication date29 May 2018
Volume34
Issue21
DOIs
Publication statusPublished - 29 May 2018

Abstract

π-Conjugated polymer nanoparticles (CPNs) are under investigation as photoluminescent agents for diagnostics and bioimaging. To determine whether the choice of surfactant can improve CPN properties and prevent protein adsorption, five nonionic polyethylene glycol alkyl ether surfactants were used to produce CPNs from three representative π-conjugated polymers. The surfactant structure did not influence size or yield, which was dependent on the nature of the conjugated polymer. Hydrophobic interaction chromatography, contact angle, quartz crystal microbalance, and neutron reflectivity studies were used to assess the affinity of the surfactant to the conjugated polymer surface and indicated that all surfactants were displaced by the addition of a model serum protein. In summary, CPN preparation methods which rely on surface coating of a conjugated polymer core with amphiphilic surfactants may produce systems with good yields and colloidal stability in vitro, but may be susceptible to significant surface alterations in physiological fluids.

ID: 15736180