University of Hertfordshire

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Intended and Unintended Use of Cathinone Mixtures

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Original languageEnglish
Article numbere2598
JournalHuman Psychopharmacology: Clinical and Experimental
Journal publication date28 Jun 2017
Volume32
Issue3
Early online date31 May 2017
DOIs
Publication statusPublished - 28 Jun 2017

Abstract

Introduction: Cathinones are one of the most popular categories of new psychoactive substances (NPS) consumed. Cathinones have different pharmacological activities and receptor selectivity for monoamine transporters based on their chemical structures. They are incorporated into NPS mixtures and used with other NPS or ‘traditional’ drugs. Cathinone use represents significant health risks to individuals, and is a public health burden. Methods Evidence of poly-NPS use with cathinones, seizure information and literature analyses results on NPS mixtures was systematically gathered from online database sources, including Google Scholar, Scopus, Bluelight and Drugs-Forum. Results and Discussion Results highlight the prevalence of NPS with low purity, incorporation of cathinones into NPS mixtures since 2008, multiple members of the cathinone family being present in individual UK-seized samples. Cathinones were identified as adulterants in NPS marketed as being pure NPS, drugs of abuse, branded products, herbal blends and products labelled “not for human consumption”. Toxicity resulting from cathinone mixtures is unpredictable since key attributes remain largely unknown. Symptoms of intoxication include neuro-psychological, psychiatric and metabolic symptoms. Proposed treatment includes holistic approaches involving psychosocial, psychiatric and pharmacological interventions. Conclusion Raising awareness of NPS, education and training of healthcare professionals is paramount in reducing harms related to cathinone use.

Notes

This is the peer reviewed version of the following article: Amira Guirguis, John Martin Corkery, Jacqueline Leslie Stair, Stewart Brian Kirton, Mire Zloh, and Fabrizio Schifano, 'Intended and unintended use o cathinone mistures', Human Psychopharmacology, Vol. 32 (3), e2598, May 2017, which has been published in final form at DOI: 10.1002/hup.2598. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Peer reviewed version is under embargo. Embargo end date: 31 May 2018. Copyright © 2017 John Wiley & Sons, Ltd.

ID: 11676017