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Is there a potential of misuse for Magnolia officinalis compounds/metabolites?

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Is there a potential of misuse for Magnolia officinalis compounds/metabolites? / Schifano, Fabrizio; Guarino, Valentina; Papanti, Duccio G.; Baccarin, Jacopo; Orsolini, Laura; Corkery, John M.

In: Human Psychopharmacology, Vol. 32, No. 3, e2595, 18.05.2017.

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Schifano, Fabrizio ; Guarino, Valentina ; Papanti, Duccio G. ; Baccarin, Jacopo ; Orsolini, Laura ; Corkery, John M. / Is there a potential of misuse for Magnolia officinalis compounds/metabolites?. In: Human Psychopharmacology. 2017 ; Vol. 32, No. 3.

Bibtex

@article{0ba58c8b9df947d1acd4022b2916c1b4,
title = "Is there a potential of misuse for Magnolia officinalis compounds/metabolites?",
abstract = "Objective: Magnolia bark contains magnolol, metabolized to tetrahydromagnolol and honokiol, with both GABA-ergic/cannabimimetic activities, hence of possible attraction to vulnerable individuals/recreational misusers. Methods: A literature review, assessment of related anecdotal online Magnolia misuse's reports and an overview of Magnolia products' online acquisition possibilities has been here described. Results: No peer-reviewed papers about Magnolia abuse/misuse/dependence/addiction were identified. Conversely, from a range of websites emerged potentially 3 groups of Magnolia misusers: (a) subjects with a psychiatric history already treated with benzodiazepines, being attracted to Magnolia bark as a “natural sedative”; (b) polydrug misusers, ingesting Magnolia with a range of other herbs/plants, attracted by the GABA-ergic/cannabimimetic activities; (c) subjects naive to the misusing drugs' scenario, perceiving Magnolia as a natural dietary supplement/weight-control compound. Conclusions: To the best of our knowledge, this is the first paper commenting on the possible Magnolia derivatives' potential of misuse. Magnolia's recent increase in popularity, mainly as a sedative, may be arguably due to its peculiar pharmacological properties/acceptable affordability levels/virtually worldwide favorable legal status and customers' attraction to a product being perceived as “natural” and hence somehow “safe.” Future/potent/synthetic magnolol and honokiol structural analogues could however contribute to increasing the number of synthetic GABA-ergic/cannabimimetic misusing compounds.",
keywords = "herbal highs, honokiol, magnolol, Novel psychoactive substances, synthetic cannabinoids, THM",
author = "Fabrizio Schifano and Valentina Guarino and Papanti, {Duccio G.} and Jacopo Baccarin and Laura Orsolini and Corkery, {John M.}",
note = "{\circledC} 2017 John Wiley & Sons, Ltd.",
year = "2017",
month = "5",
day = "18",
doi = "10.1002/hup.2595",
language = "English",
volume = "32",
journal = "Human Psychopharmacology: Clinical and Experimental",
issn = "0885-6222",
publisher = "John Wiley and Sons Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Is there a potential of misuse for Magnolia officinalis compounds/metabolites?

AU - Schifano, Fabrizio

AU - Guarino, Valentina

AU - Papanti, Duccio G.

AU - Baccarin, Jacopo

AU - Orsolini, Laura

AU - Corkery, John M.

N1 - © 2017 John Wiley & Sons, Ltd.

PY - 2017/5/18

Y1 - 2017/5/18

N2 - Objective: Magnolia bark contains magnolol, metabolized to tetrahydromagnolol and honokiol, with both GABA-ergic/cannabimimetic activities, hence of possible attraction to vulnerable individuals/recreational misusers. Methods: A literature review, assessment of related anecdotal online Magnolia misuse's reports and an overview of Magnolia products' online acquisition possibilities has been here described. Results: No peer-reviewed papers about Magnolia abuse/misuse/dependence/addiction were identified. Conversely, from a range of websites emerged potentially 3 groups of Magnolia misusers: (a) subjects with a psychiatric history already treated with benzodiazepines, being attracted to Magnolia bark as a “natural sedative”; (b) polydrug misusers, ingesting Magnolia with a range of other herbs/plants, attracted by the GABA-ergic/cannabimimetic activities; (c) subjects naive to the misusing drugs' scenario, perceiving Magnolia as a natural dietary supplement/weight-control compound. Conclusions: To the best of our knowledge, this is the first paper commenting on the possible Magnolia derivatives' potential of misuse. Magnolia's recent increase in popularity, mainly as a sedative, may be arguably due to its peculiar pharmacological properties/acceptable affordability levels/virtually worldwide favorable legal status and customers' attraction to a product being perceived as “natural” and hence somehow “safe.” Future/potent/synthetic magnolol and honokiol structural analogues could however contribute to increasing the number of synthetic GABA-ergic/cannabimimetic misusing compounds.

AB - Objective: Magnolia bark contains magnolol, metabolized to tetrahydromagnolol and honokiol, with both GABA-ergic/cannabimimetic activities, hence of possible attraction to vulnerable individuals/recreational misusers. Methods: A literature review, assessment of related anecdotal online Magnolia misuse's reports and an overview of Magnolia products' online acquisition possibilities has been here described. Results: No peer-reviewed papers about Magnolia abuse/misuse/dependence/addiction were identified. Conversely, from a range of websites emerged potentially 3 groups of Magnolia misusers: (a) subjects with a psychiatric history already treated with benzodiazepines, being attracted to Magnolia bark as a “natural sedative”; (b) polydrug misusers, ingesting Magnolia with a range of other herbs/plants, attracted by the GABA-ergic/cannabimimetic activities; (c) subjects naive to the misusing drugs' scenario, perceiving Magnolia as a natural dietary supplement/weight-control compound. Conclusions: To the best of our knowledge, this is the first paper commenting on the possible Magnolia derivatives' potential of misuse. Magnolia's recent increase in popularity, mainly as a sedative, may be arguably due to its peculiar pharmacological properties/acceptable affordability levels/virtually worldwide favorable legal status and customers' attraction to a product being perceived as “natural” and hence somehow “safe.” Future/potent/synthetic magnolol and honokiol structural analogues could however contribute to increasing the number of synthetic GABA-ergic/cannabimimetic misusing compounds.

KW - herbal highs

KW - honokiol

KW - magnolol

KW - Novel psychoactive substances

KW - synthetic cannabinoids

KW - THM

UR - http://www.scopus.com/inward/record.url?scp=85019852108&partnerID=8YFLogxK

U2 - 10.1002/hup.2595

DO - 10.1002/hup.2595

M3 - Article

VL - 32

JO - Human Psychopharmacology: Clinical and Experimental

JF - Human Psychopharmacology: Clinical and Experimental

SN - 0885-6222

IS - 3

M1 - e2595

ER -