University of Hertfordshire

From the same journal

By the same authors

  • Bernado Dell'Osso
  • Matteo Vismara
  • Beatrice Benatti
  • Giovanna Cirnigliaro
  • Benedetta Grancini
  • Michael Van Ameringen
  • Eric Hollander
  • Dan J. Stein
  • Josè M Menchon
  • Carolyn I Rodriguez
  • Humberto Nicolini
  • Nuria Lanzagorta
  • Stefano Pallanti
  • Giacomo Grassi
  • Christine Lochner
  • Donatella Marazziti
  • Georgi Hranov
  • Oguz Karamustafalioglu
  • Luchezar Hranov
  • Joseph Zohar
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Original languageEnglish
JournalCNS Spectrums
Journal publication date27 May 2019
Publication statusPublished - 27 May 2019


IntroductionBipolar disorder (BD) and obsessive compulsive disorder (OCD) are prevalent, comorbid, and disabling conditions, often characterized by early onset and chronic course. When comorbid, OCD and BD can determine a more pernicious course of illness, posing therapeutic challenges for clinicians. Available reports on prevalence and clinical characteristics of comorbidity between BD and OCD showed mixed results, likely depending on the primary diagnosis of analyzed samples.MethodsWe assessed prevalence and clinical characteristics of BD comorbidity in a large international sample of patients with primary OCD (n = 401), through the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) snapshot database, by comparing OCD subjects with vs without BD comorbidity.ResultsAmong primary OCD patients, 6.2% showed comorbidity with BD. OCD patients with vs without BD comorbidity more frequently had a previous hospitalization (p < 0.001) and current augmentation therapies (p < 0.001). They also showed greater severity of OCD (p < 0.001), as measured by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS).ConclusionThese findings from a large international sample indicate that approximately 1 out of 16 patients with primary OCD may additionally have BD comorbidity along with other specific clinical characteristics, including more frequent previous hospitalizations, more complex therapeutic regimens, and a greater severity of OCD. Prospective international studies are needed to confirm our findings.

ID: 16636846