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  • 907133

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  • Anne-Marie Minihane
  • Sophie Vinoy
  • Wendy R. Russell
  • Athanasia Baka
  • Helen M. Roche
  • Kieran M. Tuohy
  • Jessica L. Teeling
  • Ellen E. Blaak
  • Michael Fenech
  • David Vauzour
  • Harry J. McArdle
  • Bas H. A. Kremer
  • Luc Sterkman
  • Katerina Vafeiadou
  • Massimo Massi Benedetti
  • Christine M. Williams
  • Philip C. Calder
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Original languageEnglish
Number of pages14
Pages (from-to)999-1012
JournalBritish Journal of Nutrition
Journal publication date14 Oct 2015
Volume114
Issue7
Early online date31 Jul 2015
DOIs
Publication statusPublished - 14 Oct 2015

Abstract

The importance of chronic low-grade inflammation in the pathology of numerous age-related chronic conditions is now clear. An unresolved inflammatory response is likely to be involved from the early stages of disease development. The present position paper is the most recent in a series produced by the International Life Sciences Institute's European Branch (ILSI Europe). It is co-authored by the speakers from a 2013 workshop led by the Obesity and Diabetes Task Force entitled 'Low-grade inflammation, a high-grade challenge: biomarkers and modulation by dietary strategies'. The latest research in the areas of acute and chronic inflammation and cardiometabolic, gut and cognitive health is presented along with the cellular and molecular mechanisms underlying inflammation-health/disease associations. The evidence relating diet composition and early-life nutrition to inflammatory status is reviewed. Human epidemiological and intervention data are thus far heavily reliant on the measurement of inflammatory markers in the circulation, and in particular cytokines in the fasting state, which are recognised as an insensitive and highly variable index of tissue inflammation. Potential novel kinetic and integrated approaches to capture inflammatory status in humans are discussed. Such approaches are likely to provide a more discriminating means of quantifying inflammation-health/disease associations, and the ability of diet to positively modulate inflammation and provide the much needed evidence to develop research portfolios that will inform new product development and associated health claims

Notes

Copyright © ILSI Europe 2015 This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

ID: 9139845