University of Hertfordshire

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Documents

  • Michel Modo
  • William R Crum
  • Madeline Gerwig
  • Anthony C Vernon
  • Priya Patel
  • Michael J Jackson
  • Sarah Rose
  • Peter Jenner
  • Mahmoud M Iravani
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Original languageEnglish
Number of pages21
Pages (from-to)e0180733
JournalPLoS ONE
Journal publication date24 Jul 2017
Volume12
Issue7
DOIs
Publication statusPublished - 24 Jul 2017

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder producing a variety of motor and cognitive deficits with the causes remaining largely unknown. The gradual loss of the nigrostriatal pathway is currently considered the pivotal pathological event. To better understand the progression of PD and improve treatment management, defining the disease on a structural basis and expanding brain analysis to extra-nigral structures is indispensable. The anatomical complexity and the presence of neuromelanin, make the use of non-human primates an essential element in developing putative imaging biomarkers of PD. To this end, ex vivo T2-weighted magnetic resonance images were acquired from control and 1-methyl-4 phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated marmosets. Volume measurements of the caudate, putamen, and substantia nigra indicated significant atrophy and cortical thinning. Tensor-based morphometry provided a more extensive and hypothesis free assessment of widespread changes caused by the toxin insult to the brain, especially highlighting regional cortical atrophy. The results highlight the importance of developing imaging biomarkers of PD in non-human primate models considering their distinct neuroanatomy. It is essential to further develop these biomarkers in vivo to provide non-invasive tools to detect pre-symptomatic PD and to monitor potential disease altering therapeutics.

Notes

This is an open access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0, (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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