University of Hertfordshire

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Measuring Residual Renal Function in Hemodialysis Patients without Urine Collection

Research output: Contribution to journalLiterature review

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Original languageEnglish
Number of pages11
Pages (from-to)39-49
JournalSeminars in Dialysis
Journal publication date2 Jan 2017
Volume30
Issue1
Early online date18 Oct 2016
DOIs
Publication statusPublished - 2 Jan 2017

Abstract

Many patients on hemodialysis retain significant residual renal function (RRF) but currently measurement of RRF in routine clinical practice can only be achieved using inter-dialytic urine collections to measure urea and creatinine clearances. Urine collections are difficult and inconvenient for patients and staff, and therefore RRF is not universally measured. Methods to assess RRF without reliance on urine collections are needed since RRF provides useful clinical and prognostic information and also permits the application of incremental hemodialysis techniques. Significant efforts have been made to explore the use of serum based biomarkers such as cystatin C, β-trace protein and β2 -microglobulin to estimate RRF. This article reviews blood-based biomarkers and novel methods using exogenous filtration markers which show potential in estimating RRF in hemodialysis patients without the need for urine collection.

Notes

This is the peer reviewed version of the following article: Wong, J., Kaja Kamal, R. M., Vilar, E. and Farrington, K. (2017), 'Measuring Residual Renal Function in Hemodialysis Patients without Urine Collection', Seminars in Dialysis, Vol. 30 (1): 39–49, which has been published in final form at doi: 10.1111/sdi.12557. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. © 2016 Wiley Periodicals, Inc.

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