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Mucoadhesion and mucosa-mimetic materials - a mini-review

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Mucoadhesion and mucosa-mimetic materials - a mini-review. / Cook, Michael T.; Khutoryanskiy, Vitaliy V.

In: International Journal of Pharmaceutics, Vol. 495, No. 2, 30.11.2015, p. 991-998.

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Cook, Michael T. ; Khutoryanskiy, Vitaliy V. / Mucoadhesion and mucosa-mimetic materials - a mini-review. In: International Journal of Pharmaceutics. 2015 ; Vol. 495, No. 2. pp. 991-998.

Bibtex

@article{b7cdfac2610c4c1e975b14cf29d4094c,
title = "Mucoadhesion and mucosa-mimetic materials - a mini-review",
abstract = "Mucoadhesion describes an attractive interaction between dosage form and mucosal membrane. The evaluation of mucoadhesive excipients often requires the use of ex vivo mucosal tissues taken from laboratory animals. These can be difficult to source, highly heterogeneous, and require the use of animal products. Thus, from both a user-convenience and ethical point-of-view, it is desirable to produce a synthetic alternative to these tissues - a mucosa-mimetic material. In this mini-review, the use of alternative materials to test the performance of mucoadhesives is reviewed and discussed. There is a surprising prevalence of the use of mucosa-mimics in the literature, which hitherto has not been compiled and compared.",
author = "Cook, {Michael T.} and Khutoryanskiy, {Vitaliy V.}",
year = "2015",
month = "11",
day = "30",
doi = "10.1016/j.ijpharm.2015.09.064",
language = "English",
volume = "495",
pages = "991--998",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Mucoadhesion and mucosa-mimetic materials - a mini-review

AU - Cook, Michael T.

AU - Khutoryanskiy, Vitaliy V.

PY - 2015/11/30

Y1 - 2015/11/30

N2 - Mucoadhesion describes an attractive interaction between dosage form and mucosal membrane. The evaluation of mucoadhesive excipients often requires the use of ex vivo mucosal tissues taken from laboratory animals. These can be difficult to source, highly heterogeneous, and require the use of animal products. Thus, from both a user-convenience and ethical point-of-view, it is desirable to produce a synthetic alternative to these tissues - a mucosa-mimetic material. In this mini-review, the use of alternative materials to test the performance of mucoadhesives is reviewed and discussed. There is a surprising prevalence of the use of mucosa-mimics in the literature, which hitherto has not been compiled and compared.

AB - Mucoadhesion describes an attractive interaction between dosage form and mucosal membrane. The evaluation of mucoadhesive excipients often requires the use of ex vivo mucosal tissues taken from laboratory animals. These can be difficult to source, highly heterogeneous, and require the use of animal products. Thus, from both a user-convenience and ethical point-of-view, it is desirable to produce a synthetic alternative to these tissues - a mucosa-mimetic material. In this mini-review, the use of alternative materials to test the performance of mucoadhesives is reviewed and discussed. There is a surprising prevalence of the use of mucosa-mimics in the literature, which hitherto has not been compiled and compared.

U2 - 10.1016/j.ijpharm.2015.09.064

DO - 10.1016/j.ijpharm.2015.09.064

M3 - Article

C2 - 26440734

VL - 495

SP - 991

EP - 998

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 2

ER -