University of Hertfordshire

Mucosa-mimetic materials to replace animal tissue in mucoadhesion research

Research output: Contribution to conferencePoster

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Original languageEnglish
Publication statusPublished - 2016
EventDoctor Hadwen Trust Animal Replacement Science Conference -
Duration: 9 Dec 2016 → …

Conference

ConferenceDoctor Hadwen Trust Animal Replacement Science Conference
Period9/12/16 → …

Abstract

Pharmaceutical scientists often wish to design dosage forms which
adhere to mucosal membranes to provide a localised effect. These
“mucoadhesive” formulations are typically evaluated using ex vivo animal
tissue, a large amount of which is sourced from laboratory animals slaughtered
for that tissue . The authors aim to produce a synthetic alternative to this
tissue, which frees scientists from the need to use laboratory animals and
provides a substrate which is inexpensive and homogenous. A substrate
containing 20 mol% N-acryloylglucosamine (AGA) and 80 mol% 2-
hydroxyethylmethacrylate (HEMA) was identified as being an effective mimic
for buccal mucosa when testing the mucoadhesion of tablets. This study
investigates the efficacy of this “mucosa-mimetic” material when testing for the
mucoadhesion of liquid and semi-solid dosage forms.

Notes

Michael Cook, 'Mucosa-mimetic materials to replace animal tissue in mucoadhesion research', poster presented at the Doctor Hadwen Trust Animal Replacement Science Conference, London, UK, 9 December, 2016.

ID: 12089125