University of Hertfordshire

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  • 906113

    Accepted author manuscript, 413 KB, PDF-document

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Original languageEnglish
Number of pages10
Pages (from-to)414-423
JournalNanotoxicology
Journal publication dateJun 2012
Volume6
Issue4
DOIs
Publication statusPublished - Jun 2012

Abstract

The aim of this study was to investigate the actions of silver nanoparticles (nano-Ag) on glutamatergic synaptic transmission and excitability in hippocampal CA1 pyramidal neurons with whole cell patch technique. The amplitude of miniature excitatory postsynaptic currents (mEPSCs) was inhibited by silver nano-particles (nano-Ag) (10(-5) g/ml and 10(-4) g/ml), but the amplitude and frequency of spontaneous excitatory postsynaptic currents (sEPSCs) were increased by nano-Ag treatment (10(-5) g/ml and 10(-4) g/ml). Furthermore, nano-Ag (10(-5) g/ml and 10(-4) g/ml) increased the spontaneous network activity. These results provide further insights into the underlying mechanisms responsible for the effects of nano-Ag on central nervous system (CNS).

ID: 949524