University of Hertfordshire

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Original languageEnglish
Pages (from-to)439-445
JournalJournal of Applied Toxicology
Publication statusPublished - 2011


The aim of this study was to investigate the effects of nano-CuO on voltage-gated sodium current (INa) in hippocampal CA1 neurons. The results suggested that nano-CuO inhibited amplitudes of INa currents and prolonged peak rise time of action potential (AP). The responses to nano-CuO were inhibited by reactive oxygen species (ROS) scavenger. However, the G-proteins inhibitor did not block the effects of nano-CuO. The effects of nano-CuO were mediated through activation of ROS-INa-AP signaling cascades and independent from G-proteins pathway.


The definitive version can be found at: Copyright Wiley-Blackwell [Full text of this article is not available in the UHRA]

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