University of Hertfordshire

Nitrates for the Management of Acute Heart Failure Syndromes, A Systematic Review

Research output: Contribution to journalReview article

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Original languageEnglish
Pages (from-to)20-27
JournalJournal of Cardiovascular Pharmacology and Therapeutics
Journal publication date1 Jan 2017
Volume22
Issue1
Early online date25 May 2016
DOIs
Publication statusPublished - 1 Jan 2017

Abstract

Intravenous nitrates are widely used in the management of acute heart failure syndrome (AHFS) yet with lack of robust evidence to support their use. We therefore sought to analyze all randomized studies that evaluated the effects of nitrates on clinical outcomes in patients with AHFS. In total, 15 relevant trials comparing nitrates and alternative interventions in 1824 patients were identified. All but 3 were conducted before 1998. No trials demonstrated a beneficial effect on mortality, apart from 1 trial reporting a reduction in mortality, which was related to the time of treatment. Retrospective review suggests that there is a lack of data to draw any firm conclusions concerning the use of nitrates in patients with AHFS. More studies are needed to evaluate the safety and efficacy of these agents in the modern era of guideline-directed use of heart failure therapy.

Notes

© The Author(s) 2016

ID: 13240677