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Particulate matter air pollution components and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts of Air Pollution Effects (ESCAPE). / Weinmayr, Gudrun; Pedersen, Marie; Stafoggia, Massimo; Andersen, Zorana J.; Galassi, Claudia; Munkenast, Jule; Jaensch, Andrea; Oftedal, Bente; Krog, Norun H.; Aamodt, Geir; Pyko, Andrei; Pershagen, Göran; Korek, Michal; De Faire, Ulf; Pedersen, Nancy L.; Östenson, Claes Göran; Rizzuto, Debora; Sørensen, Mette; Tjønneland, Anne; Bueno-de-Mesquita, Bas; Vermeulen, Roel; Eeftens, Marloes; Concin, Hans; Lang, Alois; Wang, Meng; Tsai, Ming Yi; Ricceri, Fulvio; Sacerdote, Carlotta; Ranzi, Andrea; Cesaroni, Giulia; Forastiere, Francesco; de Hoogh, Kees; Beelen, Rob; Vineis, Paolo; Kooter, Ingeborg; Sokhi, Ranjeet; Brunekreef, Bert; Hoek, Gerard; Raaschou-Nielsen, Ole; Nagel, Gabriele.

In: Environment International, Vol. 120, 01.11.2018, p. 163-171.

Research output: Contribution to journalArticle

Harvard

Weinmayr, G, Pedersen, M, Stafoggia, M, Andersen, ZJ, Galassi, C, Munkenast, J, Jaensch, A, Oftedal, B, Krog, NH, Aamodt, G, Pyko, A, Pershagen, G, Korek, M, De Faire, U, Pedersen, NL, Östenson, CG, Rizzuto, D, Sørensen, M, Tjønneland, A, Bueno-de-Mesquita, B, Vermeulen, R, Eeftens, M, Concin, H, Lang, A, Wang, M, Tsai, MY, Ricceri, F, Sacerdote, C, Ranzi, A, Cesaroni, G, Forastiere, F, de Hoogh, K, Beelen, R, Vineis, P, Kooter, I, Sokhi, R, Brunekreef, B, Hoek, G, Raaschou-Nielsen, O & Nagel, G 2018, 'Particulate matter air pollution components and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts of Air Pollution Effects (ESCAPE)', Environment International, vol. 120, pp. 163-171. https://doi.org/10.1016/j.envint.2018.07.030

APA

Vancouver

Author

Weinmayr, Gudrun ; Pedersen, Marie ; Stafoggia, Massimo ; Andersen, Zorana J. ; Galassi, Claudia ; Munkenast, Jule ; Jaensch, Andrea ; Oftedal, Bente ; Krog, Norun H. ; Aamodt, Geir ; Pyko, Andrei ; Pershagen, Göran ; Korek, Michal ; De Faire, Ulf ; Pedersen, Nancy L. ; Östenson, Claes Göran ; Rizzuto, Debora ; Sørensen, Mette ; Tjønneland, Anne ; Bueno-de-Mesquita, Bas ; Vermeulen, Roel ; Eeftens, Marloes ; Concin, Hans ; Lang, Alois ; Wang, Meng ; Tsai, Ming Yi ; Ricceri, Fulvio ; Sacerdote, Carlotta ; Ranzi, Andrea ; Cesaroni, Giulia ; Forastiere, Francesco ; de Hoogh, Kees ; Beelen, Rob ; Vineis, Paolo ; Kooter, Ingeborg ; Sokhi, Ranjeet ; Brunekreef, Bert ; Hoek, Gerard ; Raaschou-Nielsen, Ole ; Nagel, Gabriele. / Particulate matter air pollution components and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts of Air Pollution Effects (ESCAPE). In: Environment International. 2018 ; Vol. 120. pp. 163-171.

Bibtex

@article{b201609c84c1493b826bfce0cb0c73e7,
title = "Particulate matter air pollution components and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts of Air Pollution Effects (ESCAPE)",
abstract = "Introduction: Previous analysis from the large European multicentre ESCAPE study showed an association of ambient particulate matter <2.5 μm (PM2.5) air pollution exposure at residence with the incidence of gastric cancer. It is unclear which components of PM are most relevant for gastric and also upper aerodigestive tract (UADT) cancer and some of them may not be strongly correlated with PM mass. We evaluated the association between long-term exposure to elemental components of PM2.5 and PM10 and gastric and UADT cancer incidence in European adults. Methods: Baseline addresses of individuals were geocoded and exposure was assessed by land-use regression models for copper (Cu), iron (Fe) and zinc (Zn) representing non-tailpipe traffic emissions; sulphur (S) indicating long-range transport; nickel (Ni) and vanadium (V) for mixed oil-burning and industry; silicon (Si) for crustal material and potassium (K) for biomass burning. Cox regression models with adjustment for potential confounders were used for cohort-specific analyses. Combined estimates were determined with random effects meta-analyses. Results: Ten cohorts in six countries contributed data on 227,044 individuals with an average follow-up of 14.9 years with 633 incident cases of gastric cancer and 763 of UADT cancer. The combined hazard ratio (HR) for an increase of 200 ng/m3 of PM2.5_S was 1.92 (95{\%}-confidence interval (95{\%}-CI) 1.13;3.27) for gastric cancer, with no indication of heterogeneity between cohorts (I2 = 0{\%}), and 1.63 (95{\%}-CI 0.88;3.01) for PM2.5_Zn (I2 = 70{\%}). For the other elements in PM2.5 and all elements in PM10 including PM10_S, non-significant HRs between 0.78 and 1.21 with mostly wide CIs were seen. No association was found between any of the elements and UADT cancer. The HR for PM2.5_S and gastric cancer was robust to adjustment for additional factors, including diet, and restriction to study participants with stable addresses over follow-up resulted in slightly higher effect estimates with a decrease in precision. In a two-pollutant model, the effect estimate for total PM2.5 decreased whereas that for PM2.5_S was robust. Conclusion: This large multicentre cohort study shows a robust association between gastric cancer and long-term exposure to PM2.5_S but not PM10_S, suggesting that S in PM2.5 or correlated air pollutants may contribute to the risk of gastric cancer.",
keywords = "Air pollution, Chemical elements, ESCAPE, Gastric cancer, Particulate matter components, Sulphur, Upper aerodigestive tract cancer",
author = "Gudrun Weinmayr and Marie Pedersen and Massimo Stafoggia and Andersen, {Zorana J.} and Claudia Galassi and Jule Munkenast and Andrea Jaensch and Bente Oftedal and Krog, {Norun H.} and Geir Aamodt and Andrei Pyko and G{\"o}ran Pershagen and Michal Korek and {De Faire}, Ulf and Pedersen, {Nancy L.} and {\"O}stenson, {Claes G{\"o}ran} and Debora Rizzuto and Mette S{\o}rensen and Anne Tj{\o}nneland and Bas Bueno-de-Mesquita and Roel Vermeulen and Marloes Eeftens and Hans Concin and Alois Lang and Meng Wang and Tsai, {Ming Yi} and Fulvio Ricceri and Carlotta Sacerdote and Andrea Ranzi and Giulia Cesaroni and Francesco Forastiere and {de Hoogh}, Kees and Rob Beelen and Paolo Vineis and Ingeborg Kooter and Ranjeet Sokhi and Bert Brunekreef and Gerard Hoek and Ole Raaschou-Nielsen and Gabriele Nagel",
year = "2018",
month = "11",
day = "1",
doi = "10.1016/j.envint.2018.07.030",
language = "English",
volume = "120",
pages = "163--171",
journal = "Environment International",
issn = "0160-4120",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Particulate matter air pollution components and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts of Air Pollution Effects (ESCAPE)

AU - Weinmayr, Gudrun

AU - Pedersen, Marie

AU - Stafoggia, Massimo

AU - Andersen, Zorana J.

AU - Galassi, Claudia

AU - Munkenast, Jule

AU - Jaensch, Andrea

AU - Oftedal, Bente

AU - Krog, Norun H.

AU - Aamodt, Geir

AU - Pyko, Andrei

AU - Pershagen, Göran

AU - Korek, Michal

AU - De Faire, Ulf

AU - Pedersen, Nancy L.

AU - Östenson, Claes Göran

AU - Rizzuto, Debora

AU - Sørensen, Mette

AU - Tjønneland, Anne

AU - Bueno-de-Mesquita, Bas

AU - Vermeulen, Roel

AU - Eeftens, Marloes

AU - Concin, Hans

AU - Lang, Alois

AU - Wang, Meng

AU - Tsai, Ming Yi

AU - Ricceri, Fulvio

AU - Sacerdote, Carlotta

AU - Ranzi, Andrea

AU - Cesaroni, Giulia

AU - Forastiere, Francesco

AU - de Hoogh, Kees

AU - Beelen, Rob

AU - Vineis, Paolo

AU - Kooter, Ingeborg

AU - Sokhi, Ranjeet

AU - Brunekreef, Bert

AU - Hoek, Gerard

AU - Raaschou-Nielsen, Ole

AU - Nagel, Gabriele

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Introduction: Previous analysis from the large European multicentre ESCAPE study showed an association of ambient particulate matter <2.5 μm (PM2.5) air pollution exposure at residence with the incidence of gastric cancer. It is unclear which components of PM are most relevant for gastric and also upper aerodigestive tract (UADT) cancer and some of them may not be strongly correlated with PM mass. We evaluated the association between long-term exposure to elemental components of PM2.5 and PM10 and gastric and UADT cancer incidence in European adults. Methods: Baseline addresses of individuals were geocoded and exposure was assessed by land-use regression models for copper (Cu), iron (Fe) and zinc (Zn) representing non-tailpipe traffic emissions; sulphur (S) indicating long-range transport; nickel (Ni) and vanadium (V) for mixed oil-burning and industry; silicon (Si) for crustal material and potassium (K) for biomass burning. Cox regression models with adjustment for potential confounders were used for cohort-specific analyses. Combined estimates were determined with random effects meta-analyses. Results: Ten cohorts in six countries contributed data on 227,044 individuals with an average follow-up of 14.9 years with 633 incident cases of gastric cancer and 763 of UADT cancer. The combined hazard ratio (HR) for an increase of 200 ng/m3 of PM2.5_S was 1.92 (95%-confidence interval (95%-CI) 1.13;3.27) for gastric cancer, with no indication of heterogeneity between cohorts (I2 = 0%), and 1.63 (95%-CI 0.88;3.01) for PM2.5_Zn (I2 = 70%). For the other elements in PM2.5 and all elements in PM10 including PM10_S, non-significant HRs between 0.78 and 1.21 with mostly wide CIs were seen. No association was found between any of the elements and UADT cancer. The HR for PM2.5_S and gastric cancer was robust to adjustment for additional factors, including diet, and restriction to study participants with stable addresses over follow-up resulted in slightly higher effect estimates with a decrease in precision. In a two-pollutant model, the effect estimate for total PM2.5 decreased whereas that for PM2.5_S was robust. Conclusion: This large multicentre cohort study shows a robust association between gastric cancer and long-term exposure to PM2.5_S but not PM10_S, suggesting that S in PM2.5 or correlated air pollutants may contribute to the risk of gastric cancer.

AB - Introduction: Previous analysis from the large European multicentre ESCAPE study showed an association of ambient particulate matter <2.5 μm (PM2.5) air pollution exposure at residence with the incidence of gastric cancer. It is unclear which components of PM are most relevant for gastric and also upper aerodigestive tract (UADT) cancer and some of them may not be strongly correlated with PM mass. We evaluated the association between long-term exposure to elemental components of PM2.5 and PM10 and gastric and UADT cancer incidence in European adults. Methods: Baseline addresses of individuals were geocoded and exposure was assessed by land-use regression models for copper (Cu), iron (Fe) and zinc (Zn) representing non-tailpipe traffic emissions; sulphur (S) indicating long-range transport; nickel (Ni) and vanadium (V) for mixed oil-burning and industry; silicon (Si) for crustal material and potassium (K) for biomass burning. Cox regression models with adjustment for potential confounders were used for cohort-specific analyses. Combined estimates were determined with random effects meta-analyses. Results: Ten cohorts in six countries contributed data on 227,044 individuals with an average follow-up of 14.9 years with 633 incident cases of gastric cancer and 763 of UADT cancer. The combined hazard ratio (HR) for an increase of 200 ng/m3 of PM2.5_S was 1.92 (95%-confidence interval (95%-CI) 1.13;3.27) for gastric cancer, with no indication of heterogeneity between cohorts (I2 = 0%), and 1.63 (95%-CI 0.88;3.01) for PM2.5_Zn (I2 = 70%). For the other elements in PM2.5 and all elements in PM10 including PM10_S, non-significant HRs between 0.78 and 1.21 with mostly wide CIs were seen. No association was found between any of the elements and UADT cancer. The HR for PM2.5_S and gastric cancer was robust to adjustment for additional factors, including diet, and restriction to study participants with stable addresses over follow-up resulted in slightly higher effect estimates with a decrease in precision. In a two-pollutant model, the effect estimate for total PM2.5 decreased whereas that for PM2.5_S was robust. Conclusion: This large multicentre cohort study shows a robust association between gastric cancer and long-term exposure to PM2.5_S but not PM10_S, suggesting that S in PM2.5 or correlated air pollutants may contribute to the risk of gastric cancer.

KW - Air pollution

KW - Chemical elements

KW - ESCAPE

KW - Gastric cancer

KW - Particulate matter components

KW - Sulphur

KW - Upper aerodigestive tract cancer

UR - http://www.scopus.com/inward/record.url?scp=85051021388&partnerID=8YFLogxK

U2 - 10.1016/j.envint.2018.07.030

DO - 10.1016/j.envint.2018.07.030

M3 - Article

VL - 120

SP - 163

EP - 171

JO - Environment International

JF - Environment International

SN - 0160-4120

ER -