University of Hertfordshire

  • Victoria Hutter
  • Constanze Hilgendorf
  • Vanessa Zann
  • Anne Cooper
  • David Pritchard
  • Cynthia Bosquillon
View graph of relations
Original languageEnglish
Publication statusPublished - 2011
EventUKPharmSci 2011 - Nottingham, United Kingdom
Duration: 31 Aug 20112 Sep 2011

Conference

ConferenceUKPharmSci 2011
CountryUnited Kingdom
CityNottingham
Period31/08/112/09/11

Abstract

The expression and functionality of
P-glycoprotein (P-gp) was assessed in Calu-3 cell monolayers cultured at an air-liquid interface. Net secretory transport of the established P-glycoprotein substrate 3H-digoxin was abolished at 4°C but was only marginally affected by the metabolic inhibitor sodium azide and unaffected by the specific P-gp antibody inhibitor UIC2. Results suggest that P-gp does not play a major role in the trafficking of 3H-digoxin in Calu-3 cells.

ID: 1042367