University of Hertfordshire

  • Yanjun Zhao
  • Raj Khengar
  • M.J. Traynor
  • Pedro Barata
  • Marc Brown
  • Stuart Jones
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Original languageEnglish
Pages (from-to)218-224
JournalAAPS PharmSciTech
Volume14
Issue2
DOIs
Publication statusPublished - 2012

Abstract

The intranasal (IN) administration of lorazepam is desirable in order to maximize speed of onset and minimise carry-over sedation; however, this benzodiazepine is prone to chemical hydrolysis and poor airway retention, and thus, innovative epithelial presentation is required. The aim of this study was to understand how the in situ self-assembly of a mucoretentive delivery system, formed by the dissolution of vinyl polymer-coated microparticles in the nasal mucosa, would influence lorazepam pharmacokinetics (PK).

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