University of Hertfordshire

From the same journal

By the same authors

Standard

Phenotypic factors influencing the variation in response of circulating cholesterol level to personalised dietary advice in the Food4Me study. / Kirwan, Laura; Walsh, Marianne C.; Celis-Morales, Carlos; Marsaux, Cyril F M; Livingstone, Katherine M.; Navas-Carretero, Santiago; Fallaize, Rosalind; O’Donovan, Clare B.; Woolhead, Clara; Forster, Hannah; Kolossa, Silvia; Daniel, Hannelore; Moschonis, George; Manios, Yannis; Surwillo, Agnieszka; Godlewska, Magdalena; Traczyk, Iwona; Drevon, Christian A.; Gibney, Mike J.; Lovegrove, Julie A.; Martinez, J. Alfredo; Saris, Wim H M; Mathers, John C.; Gibney, Eileen R.; Brennan, Lorraine.

In: British Journal of Nutrition, Vol. 116, No. 12, 28.12.2016, p. 2011-2019.

Research output: Contribution to journalArticle

Harvard

Kirwan, L, Walsh, MC, Celis-Morales, C, Marsaux, CFM, Livingstone, KM, Navas-Carretero, S, Fallaize, R, O’Donovan, CB, Woolhead, C, Forster, H, Kolossa, S, Daniel, H, Moschonis, G, Manios, Y, Surwillo, A, Godlewska, M, Traczyk, I, Drevon, CA, Gibney, MJ, Lovegrove, JA, Martinez, JA, Saris, WHM, Mathers, JC, Gibney, ER & Brennan, L 2016, 'Phenotypic factors influencing the variation in response of circulating cholesterol level to personalised dietary advice in the Food4Me study', British Journal of Nutrition, vol. 116, no. 12, pp. 2011-2019. https://doi.org/10.1017/S0007114516004256

APA

Kirwan, L., Walsh, M. C., Celis-Morales, C., Marsaux, C. F. M., Livingstone, K. M., Navas-Carretero, S., ... Brennan, L. (2016). Phenotypic factors influencing the variation in response of circulating cholesterol level to personalised dietary advice in the Food4Me study. British Journal of Nutrition, 116(12), 2011-2019. https://doi.org/10.1017/S0007114516004256

Vancouver

Author

Kirwan, Laura ; Walsh, Marianne C. ; Celis-Morales, Carlos ; Marsaux, Cyril F M ; Livingstone, Katherine M. ; Navas-Carretero, Santiago ; Fallaize, Rosalind ; O’Donovan, Clare B. ; Woolhead, Clara ; Forster, Hannah ; Kolossa, Silvia ; Daniel, Hannelore ; Moschonis, George ; Manios, Yannis ; Surwillo, Agnieszka ; Godlewska, Magdalena ; Traczyk, Iwona ; Drevon, Christian A. ; Gibney, Mike J. ; Lovegrove, Julie A. ; Martinez, J. Alfredo ; Saris, Wim H M ; Mathers, John C. ; Gibney, Eileen R. ; Brennan, Lorraine. / Phenotypic factors influencing the variation in response of circulating cholesterol level to personalised dietary advice in the Food4Me study. In: British Journal of Nutrition. 2016 ; Vol. 116, No. 12. pp. 2011-2019.

Bibtex

@article{f8f6c9b69f8a42c7a51b91574f81af8d,
title = "Phenotypic factors influencing the variation in response of circulating cholesterol level to personalised dietary advice in the Food4Me study",
abstract = "Individual response to dietary interventions can be highly variable. The phenotypic characteristics of those who will respond positively to personalised dietary advice are largely unknown. The objective of this study was to compare the phenotypic profiles of differential responders to personalised dietary intervention, with a focus on total circulating cholesterol. Subjects from the Food4Me multi-centre study were classified as responders or non-responders to dietary advice on the basis of the change in cholesterol level from baseline to month 6, with lower and upper quartiles defined as responder and non-responder groups, respectively. There were no significant differences between demographic and anthropometric profiles of the groups. Furthermore, with the exception of alcohol, there was no significant difference in reported dietary intake, at baseline. However, there were marked differences in baseline fatty acid profiles. The responder group had significantly higher levels of stearic acid (18 : 0, P=0·034) and lower levels of palmitic acid (16 : 0, P=0·009). Total MUFA (P=0·016) and total PUFA (P=0·008) also differed between the groups. In a step-wise logistic regression model, age, baseline total cholesterol, glucose, five fatty acids and alcohol intakes were selected as factors that successfully discriminated responders from non-responders, with sensitivity of 82 {\%} and specificity of 83 {\%}. The successful delivery of personalised dietary advice may depend on our ability to identify phenotypes that are responsive. The results demonstrate the potential use of metabolic profiles in identifying response to an intervention and could play an important role in the development of precision nutrition.",
keywords = "Cholesterol, Fatty acid profiles, Personalised nutrition, Phenotypes, Responders",
author = "Laura Kirwan and Walsh, {Marianne C.} and Carlos Celis-Morales and Marsaux, {Cyril F M} and Livingstone, {Katherine M.} and Santiago Navas-Carretero and Rosalind Fallaize and O’Donovan, {Clare B.} and Clara Woolhead and Hannah Forster and Silvia Kolossa and Hannelore Daniel and George Moschonis and Yannis Manios and Agnieszka Surwillo and Magdalena Godlewska and Iwona Traczyk and Drevon, {Christian A.} and Gibney, {Mike J.} and Lovegrove, {Julie A.} and Martinez, {J. Alfredo} and Saris, {Wim H M} and Mathers, {John C.} and Gibney, {Eileen R.} and Lorraine Brennan",
note = "{\circledC} The Authors 2017",
year = "2016",
month = "12",
day = "28",
doi = "10.1017/S0007114516004256",
language = "English",
volume = "116",
pages = "2011--2019",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "12",

}

RIS

TY - JOUR

T1 - Phenotypic factors influencing the variation in response of circulating cholesterol level to personalised dietary advice in the Food4Me study

AU - Kirwan, Laura

AU - Walsh, Marianne C.

AU - Celis-Morales, Carlos

AU - Marsaux, Cyril F M

AU - Livingstone, Katherine M.

AU - Navas-Carretero, Santiago

AU - Fallaize, Rosalind

AU - O’Donovan, Clare B.

AU - Woolhead, Clara

AU - Forster, Hannah

AU - Kolossa, Silvia

AU - Daniel, Hannelore

AU - Moschonis, George

AU - Manios, Yannis

AU - Surwillo, Agnieszka

AU - Godlewska, Magdalena

AU - Traczyk, Iwona

AU - Drevon, Christian A.

AU - Gibney, Mike J.

AU - Lovegrove, Julie A.

AU - Martinez, J. Alfredo

AU - Saris, Wim H M

AU - Mathers, John C.

AU - Gibney, Eileen R.

AU - Brennan, Lorraine

N1 - © The Authors 2017

PY - 2016/12/28

Y1 - 2016/12/28

N2 - Individual response to dietary interventions can be highly variable. The phenotypic characteristics of those who will respond positively to personalised dietary advice are largely unknown. The objective of this study was to compare the phenotypic profiles of differential responders to personalised dietary intervention, with a focus on total circulating cholesterol. Subjects from the Food4Me multi-centre study were classified as responders or non-responders to dietary advice on the basis of the change in cholesterol level from baseline to month 6, with lower and upper quartiles defined as responder and non-responder groups, respectively. There were no significant differences between demographic and anthropometric profiles of the groups. Furthermore, with the exception of alcohol, there was no significant difference in reported dietary intake, at baseline. However, there were marked differences in baseline fatty acid profiles. The responder group had significantly higher levels of stearic acid (18 : 0, P=0·034) and lower levels of palmitic acid (16 : 0, P=0·009). Total MUFA (P=0·016) and total PUFA (P=0·008) also differed between the groups. In a step-wise logistic regression model, age, baseline total cholesterol, glucose, five fatty acids and alcohol intakes were selected as factors that successfully discriminated responders from non-responders, with sensitivity of 82 % and specificity of 83 %. The successful delivery of personalised dietary advice may depend on our ability to identify phenotypes that are responsive. The results demonstrate the potential use of metabolic profiles in identifying response to an intervention and could play an important role in the development of precision nutrition.

AB - Individual response to dietary interventions can be highly variable. The phenotypic characteristics of those who will respond positively to personalised dietary advice are largely unknown. The objective of this study was to compare the phenotypic profiles of differential responders to personalised dietary intervention, with a focus on total circulating cholesterol. Subjects from the Food4Me multi-centre study were classified as responders or non-responders to dietary advice on the basis of the change in cholesterol level from baseline to month 6, with lower and upper quartiles defined as responder and non-responder groups, respectively. There were no significant differences between demographic and anthropometric profiles of the groups. Furthermore, with the exception of alcohol, there was no significant difference in reported dietary intake, at baseline. However, there were marked differences in baseline fatty acid profiles. The responder group had significantly higher levels of stearic acid (18 : 0, P=0·034) and lower levels of palmitic acid (16 : 0, P=0·009). Total MUFA (P=0·016) and total PUFA (P=0·008) also differed between the groups. In a step-wise logistic regression model, age, baseline total cholesterol, glucose, five fatty acids and alcohol intakes were selected as factors that successfully discriminated responders from non-responders, with sensitivity of 82 % and specificity of 83 %. The successful delivery of personalised dietary advice may depend on our ability to identify phenotypes that are responsive. The results demonstrate the potential use of metabolic profiles in identifying response to an intervention and could play an important role in the development of precision nutrition.

KW - Cholesterol

KW - Fatty acid profiles

KW - Personalised nutrition

KW - Phenotypes

KW - Responders

UR - http://www.scopus.com/inward/record.url?scp=85008626134&partnerID=8YFLogxK

U2 - 10.1017/S0007114516004256

DO - 10.1017/S0007114516004256

M3 - Article

VL - 116

SP - 2011

EP - 2019

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 12

ER -