University of Hertfordshire

  • Bayissi Bading-Taika
  • Tunde Akinyeke
  • Armando Alcazar Maganad
  • Jaewoo Choie
  • Michael Ouanesisouk
  • Eileen Ruth Samson Torres
  • Lisa Lione
  • Claudia S. Maier
  • Gerd Bobe
  • Jacob Raber
  • Cristobal L. Miranda
  • Jan F Stevens
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Original languageEnglish
Number of pages13
Pages (from-to)111-123
JournalJournal of Food Bioactives
Journal publication date1 Sep 2018
Volume3
DOIs
Publication statusPublished - 1 Sep 2018

Abstract

Preparations of the root bark of Tabernanthe iboga have long been used in Central and West African traditional medicine to combat fatigue, as a neuro-stimulant in rituals, and for treatment of diabetes. The principal alkaloid of T. iboga, ibogaine, has attracted attention in many countries around the world for providing relief for opioid craving in drug addicts. Using a plant metabolomics approach, we detected five phenolic compounds, including 3- O-caffeoylquinic acid, and 30 alkaloids, seven of which were previously reported from T. iboga root bark. Following a report that iboga extracts contain insulinotropic agents, we aimed to determine the potential alleviating effects of the water extract of iboga root bark on high-fat diet (HFD)-induced hyperglycemia as well as its effects on cognitive function in male C57BL/6J mice. Feeding a HFD to mice for 10 weeks produced manifestations of metabolic syndrome such as increased body weight and increased plasma levels of glucose, triacylglycerols, total cholesterol, LDL-cholesterol, insulin, leptin, and pro-inflammatory mediators (IL-6, MCP-1, ICAM-1), as compared to mice fed a low-fat diet (LFD). Supplementation of HFD with iboga extract at ibogaine doses of 0.83 (low) and 2.07 (high) mg/kg/day did not improve these HFD-induced metabolic effects except for a reduction of plasma MCP-1 in the low dose group, indicative of an anti-inflammatory effect. When the HFD mice were tested in the water maze, the high-dose iboga extract caused hippocampus-dependent impairments in spatial learning and memory, as compared to mice receiving only a HFD.

ID: 14876030